Chromosomal Instability and Aging: Basic Science and Clinical Implications Book

	Foreword
	Preface
	Contributors
1	Introduction	1
2	Overview of Chromosomal Instability and Aging Mechanisms	9
3	Cellular Senescence	29
4	Telomeric Shortening and Replicative Aging	51
5	Telomeric Regulation in Eukaryotic Cells	73
6	Role of Ku at the Telomere	107
7	Chromosomal Instability in Normative Aging	125
8	Chromatin, Aging, and Cellular Senescence	149
9	Werner Syndrome	167
10	Bloom Syndrome: Genetic, Cellular, and Molecular Features as Compared to Werner Syndrome	187
11	Molecular Biology of Rothmund-Thomson Syndrome	223
12	Hutchinson-Gilford Progeria Syndrome	245
13	Ataxia-Telangiectasia	263
14	Nijmegen Breakage Syndrome	311
15	Dyskeratosis Congenita	345
16	Genetic Instability and Fanconi Anemia	375
17	Xeroderma Pigmentosum	409
18	Down Syndrome	441
19	Genomic Instability and Yeast Aging	465
20	Genetics of Aging in the Nematode Caenorhabditis elegans	493
21	Aging, Somatic Maintenance, and Genomic Stability in Drosophila melanogaster	509
22	Telomerase-Deficient Mouse Model	523
23	Animal Models of Oxidative Stress and Aging	547
24	Conclusions and Future Directions	565
	Index	575