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Foreword | ||
Contributors | ||
Pt. I | Overview | 1 |
Pt. II | Receptors and G-proteins | 5 |
1 | Cell Surface Receptors: Mechanisms of Signaling and Inactivation | 7 |
2 | Heterotrimeric G-proteins: Structure, Regulation, and Signaling Mechanisms | 29 |
3 | Ras- and Rho-Related Small Molecular Weight G-proteins: Structure and Signaling Mechanisms | 47 |
Pt. III | Second Messengers | 65 |
4 | Cyclic Nucleotides: Synthesis by Adenylyl and Guanylyl Cyclases | 67 |
5 | Phospholipases: Generation of Lipid-Derived Second Messengers | 89 |
6 | Cyclic Nucleotide Phosphodiesterases: Structural and Functional Aspects | 147 |
Pt. IV | Novel Messengers | 175 |
7 | Nitric Oxide: Synthesis and Intracellular Actions | 177 |
Pt. V | Regulatory Mechanisms and Ion Transport in Signal Transduction | 213 |
8 | Ionic Channels Mediating Sensory Transduction | 215 |
9 | Bits for an Organic Microprocessor: Protein Phosphorylation/Dephosphorylation | 235 |
Pt. VI | Applications of Signal Transduction in Disease and Drug Abuse | 265 |
10 | Defects in Signal Transduction Proteins Leading to Disease | 267 |
11 | Intracellular Messengers in Drug Addiction | 287 |
Keyword Index | 305 |
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