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Drug Resistance, Vol. 87 Book

Drug Resistance, Vol. 87
Drug Resistance, Vol. 87, , Drug Resistance, Vol. 87 has a rating of 3 stars
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Drug Resistance, Vol. 87, , Drug Resistance, Vol. 87
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  • Drug Resistance, Vol. 87
  • Written by author William N. Hait
  • Published by Springer-Verlag New York, LLC, December 2009
  • Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity
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Authors

List of Contributors
Introduction
1P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal3
2Multidrug Resistance Associated with Overexpression of MRP39
3Mechanisms of Resistance to Alkylating Agents65
4Glutathione S-Transferases83
5Role of DNA Repair in Resistance to Drugs that Alkylate O[superscript 6] of Guanine123
6Paclitaxel (Taxol): Mechanisms of Resistance149
7Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy175
8Antifolates: Current Developments197
9Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance225
10Cellular Resistance to Topoisomerase Poisons243
11Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms263
12Androgen Receptor Mutations in Prostate Cancer285
13Retinoids in Clinical Cancer Therapy305
14Apoptosis and Cancer Chemotherapy345
15Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma357
16Multifunctional Modulators of Drug Resistance381
Index409


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