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List of Contributors | ||
Introduction | ||
1 | P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal | 3 |
2 | Multidrug Resistance Associated with Overexpression of MRP | 39 |
3 | Mechanisms of Resistance to Alkylating Agents | 65 |
4 | Glutathione S-Transferases | 83 |
5 | Role of DNA Repair in Resistance to Drugs that Alkylate O[superscript 6] of Guanine | 123 |
6 | Paclitaxel (Taxol): Mechanisms of Resistance | 149 |
7 | Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy | 175 |
8 | Antifolates: Current Developments | 197 |
9 | Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance | 225 |
10 | Cellular Resistance to Topoisomerase Poisons | 243 |
11 | Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms | 263 |
12 | Androgen Receptor Mutations in Prostate Cancer | 285 |
13 | Retinoids in Clinical Cancer Therapy | 305 |
14 | Apoptosis and Cancer Chemotherapy | 345 |
15 | Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma | 357 |
16 | Multifunctional Modulators of Drug Resistance | 381 |
Index | 409 |
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