Molecular Physiology And Pharmacology Of Cardiac Ion Chanels And Transporters, Vol. 182 Book

	List of Contributors
	Preface
	Thoughts of my friend, Hiroshi Irisawa
	Dr Hiroshi Irisawa during his youth and physiology
1	Overview: channels and channel proteins	3
2	The hyperpolarization-activated inward channel and cardiac pacemaker activity	17
3	The hyperpolarization-activated (I[subscript f]) current: autonomic regulation and the control of pacing	31
4	Current understanding of the structure of the voltage gated sodium channel	39
5	[beta]-adrenergic regulation of cardiac Na[superscript +] channel	53
6	L-type calcium channel structure and function	63
7	L-type Ca channel biophysics	71
8	[beta]-adrenergic and muscarinic regulation of L-type calcium current	81
9	Regulation of cardiac Ca[superscript 2+] channels by cGMP and NO	93
10	Diversity of voltage-dependent K channels	107
11	Cloned human heart delayed rectifier K[superscript +] channels	119
12	Primary structure and biophysical properties of inward rectifying K[superscript +] channel family	131
13	Ca[superscript 2+]-dependent transient outward current in mammalian heart	141
14	Delayed potassium channels in the heart: regulatory and molecular properties	169
15	Muscarinic and purinergic regulation of cardiac K[superscript +] channels	177
16	Chloride channels in heart	187
17	Properties of cardiac ATP-sensitive potassium channels	197
18	Physiological and molecular properties of cardiac gap junctions	209
19	Volume-regulated cardiac ion channels	223
20	Regulation of cardiac activity by ATP, a purine agonist	231
21	Developmental aspects of cardiac ion channels	241
22	Developmental changes and regulation of L-type calcium channels of myocardial cells and vascular smooth muscle cells	251
23	Pharmacology of the calcium channel antagonists	275
24	Interactions of calcium antagonists and agonists with calcium channels in muscle cells	291
25	Pharmacological regulation of the cardiac ATP-sensitive K[superscript +] channel	305
26	Fatty acids and cardiac K[superscript +] channels	313
27	Sodium channels and block	323
28	Afterdepolarizations triggered rhythms and cardiac arrhythmias	333
29	Transient inward current and triggered activity	343
30	The Na[superscript +]-activated K[superscript +] channel	351
31	Regulation of cardiac ATP-sensitive K channels during ischemia, hypoxia and impaired metabolism	357
32	Signaling of calcium release in cardiac muscle	375
33	Local calcium transients in voltage-clamped cardiac cells: evoked 'calcium sparks'	381
34	Sarcoplasmic recticulum ryanodine receptor/Ca[superscript 2+] release channel: a functional perspective	389
35	Molecular structure of calcium release channels	397
36	Sarcoplasmic reticulum Ca[superscript 2+] ATPases	411
37	Molecular structure and function of phospholamban	427
38	Na[superscript +]-Ca[superscript 2+] exchanger: molecular aspects	435
39	Na/Ca exchanger: molecular and cellular characteristics
40	The functional significance of sodium-calcium exchange	457
41	The physiology of the Na-Ca exchange	469
42	Regulation of cardiac relaxation	481
43	Evaluation of changes in myofibrillar Ca[superscript 2+] sensitivity in intact cardiac cells	513
44	[alpha]-Adrenergic receptor-dependent regulation of myocardial contractility	531
45	Ca transport from the cytoplasm and dynamic cellular Ca balance in cardiac myocytes	541
46	Regulation of intracellular protons: role of Na/H exchange in cardiac myocytes	555
47	Magnesium homeostasis and cardiac cell function	563
48	Na-K pump: multiple isoforms and their roles in cardiac functions	575
	Index	583