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Recent Advances In Clinical Trial Design And Analysis, Vol. 75 Book

Recent Advances In Clinical Trial Design And Analysis, Vol. 75
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  • Recent Advances In Clinical Trial Design And Analysis, Vol. 75
  • Written by author Peter F. Thall
  • Published by Springer-Verlag New York, LLC, June 1995
  • Clinical trials have two purposes — to treat the patients in the trial, and to obtain information which increases our understanding of the disease and especially how patients respond to treatment. Statistical design provides a means to achieve both t
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List of Contributors
Preface
1The alpha spending function approach to interim data analyses1
2Issues in the design and analysis of AIDS clinical trials29
3Recent developments in the design of phase II clinical trials49
4Multivariate failure time data73
5Goodness-of-fit and diagnostics for proportional hazards regression models95
6A review of tree-based prognostic models113
7Decision analysis and Bayesian methods in clinical trials125
8A Bayesian model for evaluating specificity of treatment effects in clinical trials155
9The exact analysis of contingency tables in medical research177
10Stratified-adjusted versus unstratified assessment of sample size and power for analyses of proportions203
11Quality-of-life assessment in clinical trials225
Index247


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