Hemostasis and Thrombosis: Basic Principles and Clinical Practice Book

	Overview of hemostasis	3
	Overview of coagulation, fibrinolysis, and their regulation	17
	The blood coagulation factors : their complementary DNAs, genes, and expression	21
	Genetics of coagulation	59
	Tissue factor structure and function	91
	Contact activation (Kallikrein-Kinin) pathway : multiple physiologic and pathophysiologic activities	107
	Molecular and structural biology of factor IX	131
	Factor VIII and hemophilia A	151
	Factor V	177
	Thrombin	193
	Protein Z and protein Z-dependent protease inhibitor	215
	Factor XI	221
	Antithrombin III and heparin cofactor II	235
	Protein C, protein S, and thrombomodulin	249
	Heparin and vascular proteoglycans	271
	Fibrinogen structure and physiology	285
	Factor XIII and fibrin stabilization	317
	Plasminogen - plasmin system	335
	Plasminogen activator inhibitor-1	365
	Thrombin-activatable fibrinolysis inhibitor aka procarboxypeptidase U	381
	[alpha]-Macroglobulins and kunins	395
	Human endothelial cell plasmin-generating system	409
	Physiologic regulation of fibrinolysis	419
	Overview of platelet structure and function	437
	Platelet production : cellular and molecular regulation	443
	Platelets : structure related to function	463
	Thrombopoietin	483
	Platelet glycoprotein polymorphisms and relationship to function, immunogenicity, and disease	493
	Molecular mechanisms of drug-induced thrombocytopenia	507
	Integrin [alpha][subscript IIb][beta][subscript 3] and platelet aggregation	517
	The platelet glycoprotein Ib/IX/V complex and platelet adhesion	531
	Platelet adenosine 5'-diphosphate receptors	547
	Protease-activated receptors in hemostasis, thrombosis, and vascular biology	555
	Platelet - collagen receptors	567
	Platelet prostanoid receptors	575
	Platelet eicosanoids	583
	Platelet and megakaryocyte lipids	591
	Role of platelets in blood coagulation	605
	Platelet signal transduction	617
	Overview of vascular biology, embryogenesis, development, and disorders	631
	Development of the vascular system	633
	The vascular biology of nitric oxide and nitric oxide synthases	653
	Vascular adaptations to altered blood flow	667
	Angiogenesis, lymphangiogenesis, and vascular morphogenesis	679
	Monocyte-platelet-endothelial interactions	691
	Structure and function of von willebrand factor	707
	Platelet-vessel wall interactions in flowing blood	723
	Rheology of thrombosis	737
	Biomaterial-associated thrombosis	751
	The vascular response to injury	761
	Vessel wall lipids	769
	Thrombophilia genetics	779
	Inflammation and atherothrombosis	795
	Histopathology of atherosclerosis	813
	Laboratory markers of platelet activation	825
	Laboratory markers of coagulation and fibrinolysis	835
	Malignancy and hemostasis	851
	Overview of inherited hemorrhagic disorders	877
	Clinical manifestations and therapy of the hemophilias	887
	von Willebrand disease : diagnosis, classification, and treatment	905
	Inherited disorders of prothrombin conversion	923
	Afibrinogenemias and dysfibrinogenemias	939
	Familial multiple coagulation factor deficiencies	953
	Hereditary disorders of platelet secretion and signal transduction	961
	Inherited thrombocytopenias	975
	Inherited abnormalities of the platelet membrane : Glanzmann Thrombasthenia, Bernard-Soulier syndrome, and other disorders	987
	Primary vascular disorders	1011
	Hemostatic abnormalities in liver disease	1025
	Clinical disorders of fibrinolysis	1035
	Acquired qualitative platelet defects	1045
	Acquired disorders of coagulation : the immune coagulopathies	1061
	Immune thrombocytopenic purpura	1085
	Drug-induced thrombocytopenia	1095
	Hemostatic problems in surgical patients	1103
	Obstetric hemorrhage	1121
	Clinical approach to the bleeding patient	1147
	Management of acute hemorrhage	1159
	Therapy with antifibrinolytic agents	1173
	Transfusion medicine platelet transfusion therapy, plasma, and plasma concentrates	1193
	New approaches for the therapy of bleeding disorders, including gene therapy	1205
	Overview of venous thromboembolism	1219
	Epidemiology of venous thromboembolism	1227
	Women's health and venous thromboembolism	1235
	Cancer and thrombosis	1251
	Venous thrombosis in unusual sites	1263
Pt. I	Upper extremity deep vein thrombosis
Pt. II	Cranial and Abdominal Venous Thrombosis
	Diagnosis of venous thromboembolism	1279
	Risk stratification in patients with pulmonary embolism	1299
	Treatment of venous thromboembolism	1307
	Thrombolysis in venous thromboembolic disease	1317
	Mechanical devices and embolectomy	1331
	Chronic thromboembolic pulmonary hypertension	1339
	Paradoxical embolism	1351
	Prevention of venous thromboembolism in general surgery	1361
	Prevention of venous thromboembolism in orthopedic surgery	1369
	Venous thromboprophylaxis in medical patients	1381
	Acute coronary syndromes	1387
	Antithrombotic therapy for percutaneous coronary intervention	1405
	Coronary bypass grafting and cardiac surgery	1433
	Medical therapy for peripheral arterial disease	1441
	Surgery for peripheral arterial disease	1453
	Prevention and treatment of acute stroke	1477
	Interdisciplinary management of acute stroke	1497
	Antithrombotic therapy for patients with atrial fibrillation	1517
	Advanced cardiomyopathy and surgery	1529
	Valvular heart disease	1539
	Overview of complex thrombohemorrhagic disorders	1553
	Myeloproliferative disorders and thrombohemorrhagic complications	1557
	Consumptive thrombohemorrhagic disorders	1571
	Coagulation abnormalities in sepsis	1601
	Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome	1613
	Antiphospholipid antibodies and the antiphospholipid syndrome	1621
	Thrombosis in infancy and childhood	1637
	Heparin-induced thrombocytopenia	1649
	Coumarin-induced skin necrosis and venous limb gangrene	1663
	Anticoagulant therapy for major arterial and venous thromboembolism	1673
	Anticoagulation clinics	1689
	Drug interactions with oral anticoagulants	1699
	Hemorrhagic complications of anticoagulation	1707
	Antiplatelet therapy	1725
	Foundations of thrombolytic therapy	1739
	New thrombolytic agents	1753
	New antithrombotic drugs	1763