Antiepileptic Drugs, , Antiepileptic Drugs Book, Antiepileptic Dr

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Preface
Sect. I General Principles 1
1 Principles of Antiepileptic Drug Action 3
2 Neurophysiological Effects of Antiepileptic Drugs 23
3 Discovery and Preclinical Development of Antiepileptic Drugs 36
4 New Antiepileptic Drug Development: Medical Perspective 49
5 Clinical Development of Antiepileptic Drugs: Industry Perspective 58
6 The Development of Antiepilepsy Drugs: Regulatory Perspective 66
7 Antiepileptic Drug Monotherapy in Adults: Selection and Use in New-Onset Epilepsy 72
8 Combination Therapy and Drug Interactions 96
9 Laboratory Monitoring of Antiepileptic Drugs 103
10 Safety Monitoring of Antiepileptic Drugs 112
11 Use of Antiepileptic Drugs in Children 119
12 Antiepileptic Drug Use in Women 132
13 Epilepsy in the Elderly 149
14 Treatment of Status Epilepticus 159
15 Prevention of Epileptogenesis 169
Sect. II Benzodiazepines 177
16 Mechanisms of Action 179
17 Chemistry, Biotransformation, and Pharmacokinetics 187
18 Clinical Efficacy and Use in Epilepsy 206
19 Adverse Effects 215
Sect. III Carbamazepine 225
20 Mechanisms of Action 227
21 Chemistry, Biotransformation, and Pharmacokinetics 236
22 Interactions with Other Drugs 247
23 Clinical Efficacy and Use in Epilepsy 262
24 Clinical Efficacy and Use in Other Neurological Disorders 273
25 Clinical Efficacy and Use in Psychiatric Disorders 278
26 Adverse Effects 285
Sect. IV Felbamate 299
27 Felbamate 301
Sect. V Gabapentin 319
28 Mechanisms of Action 321
29 Chemistry, Biotransformation, Pharmacokinetics, and Interactions 335
30 Clinical Use 340
31 Clinical Efficacy and Use in Other Neurological Disorders 344
32 Clinical Efficacy and Use in Psychiatric Disorders 349
33 Adverse Effects 354
Sect. VI Lamotrigine 361
34 Mechanisms of Action 363
35 Chemistry, Biotransformation, and Pharmacokinetics 370
36 Interactions with Other Drugs 380
37 Clinical Efficacy and Use in Epilepsy 389
38 Efficacy and Use in Nonepileptic Disorders 403
39 Adverse Effects 408
Sect. VII Levetiracetam 417
40 Mechanisms of Action 419
41 Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions 428
42 Clinical Use 433
43 Adverse Experiences 442
Sect. VIII Oxcarbazepine 449
44 Mechanisms of Action 451
45 Chemistry, Biotransformation, and Pharmacokinetics 459
46 Interactions with Other Drugs 466
47 Clinical Efficacy and Use in Epilepsy 470
48 Clinical Efficacy and Use in Psychiatric Disorders 476
49 Adverse Effects 479
Sect. IX Phenobarbital and Other Barbiturates 487
50 Mechanisms of Action 489
51 Chemistry, Biotransformation, and Pharmacokinetics 496
52 Interactions with Other Drugs 504
53 Clinical Efficacy and Use in Epilepsy 514
54 Clinical Efficacy and Use in Nonepileptic Disorders 522
55 Adverse Effects 528
56 Methylphenobarbital 541
Sect. X Phenytoin and Other Hydantoins 549
57 Mechanisms of Action 551
58 Chemistry and Biotransformation 565
59 Interactions with Other Drugs 581
60 Clinical Efficacy and Use in Epilepsy 591
61 Clinical Efficacy and Use in Other Neurological Disorders 597
62 Clinical Efficacy and Use in Psychiatric Disorders 600
63 Adverse Effects 605
64 Fosphenytoin 611
Sect. XI Primidone 619
65 Primidone 621
Sect. XII Succinimides 637
66 Mechanisms of Action 639
67 Ethosuximide: Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions 646
68 Clinical Efficacy and Use in Epilepsy 652
69 Adverse Effects 658
70 Methsuximide 665
Sect. XIII Tiagabine 673
71 Mechanisms of Action 675
72 Chemistry, Biotransformation, and Pharmacokinetics 681
73 Drug Interactions 691
74 Clinical Efficacy and Use in Epilepsy 698
75 Clinical Efficacy and Use in Nonepileptic Disorders 705
76 Adverse Effects 711
Sect. XIV Topiramate 717
77 Mechanisms of Action 719
78 Chemistry, Biotransformation, and Pharmacokinetics 727
79 Drug Interactions 735
80 Clinical Efficacy and Use in Epilepsy 740
81 Clinical Efficacy and Use in Nonepileptic Disorders 753
82 Adverse Effects 760
Sect. XV Valproic Acid 765
83 Mechanisms of Action 767
84 Chemistry, Biotransformation, and Pharmacokinetics 780
85 Drug Interactions 801
86 Clinical Efficacy and Use in Epilepsy 808
87 Clinical Efficacy and Use in Other Neurological Disorders 818
88 Clinical Efficacy and Use in Psychiatric Disorders 828
89 Adverse Effects 837
Sect. XVI Vigabatrin 853
90 Vigabatrin 855
Sect. XVII Zonisamide 865
91 Mechanisms of Action 867
92 Chemistry, Biotransformation, and Pharmacokinetics 873
93 Drug Interactions 880
94 Clinical Efficacy and Use in Epilepsy 885
95 Adverse Effects 892
Sect. XVIII Drugs in Development 899
96 Pregabalin 901
97 Rufinamide 906
98 Drugs in Early Clinical Development 913
Subject Index 929

Title: Antiepileptic Drugs

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WonderClub

Item Number: 9780781723213

Publication Date: June 2002

Product Description: Antiepileptic Drugs

Universal Product Code (UPC): 9780781723213

WonderClub Stock Keeping Unit (WSKU): 9780781723213

Rating: 4/5 based on 2 Reviews

Image Location: https://wonderclub.com/images/covers/32/13/9780781723213.jpg

Category: Media >> Books

Weight: 0.200 kg (0.44 lbs)

Width: 0.000 cm (0.00 inches)

Heigh : 0.000 cm (0.00 inches)

Depth: 0.000 cm (0.00 inches)

Date Added: August 25, 2020, Added By: Ross

Date Last Edited: August 25, 2020, Edited By: Ross

Price	Condition	Delivery	Seller	Action
$179.00	Digital	Arrives between May 9 - Jun 8 Login to your account for a direct download. Some files are emailed from Dropbox. Continent $0.00 - World $0.00	WonderClub (9296 total ratings)

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EDWARD GONZALEZ

reviewed Antiepileptic Drugs on February 24, 2013

Antiepileptic Drugs

The thing with me is that I don't get anything. Here's an example: I want to find out about viruses, so I track down the best book I can about viruses and I read it, and now if you ask me what a virus is I can say things. They hijack a cell's normal function so that it makes copies of the virus's DNA, instead of copies of their own DNA. Something like that. Amazing, I am so smart. But what if you ask me what a cell is? Or what DNA is? I can keep saying things - the cell is the factory of the human body, DNA is the blueprint for life - but I'm just saying things, dude. I'm a fucking parrot. Understanding a thing metaphorically is not the same as understanding the actual thing. I don't really, at a core level, know what I'm talking about, almost ever.

metaphor

So I know it's sortof a cliche to get all "the older I get the more I realize I don't know" or whatever it is old people say, and also it's untrue in my case because I didn't think I knew anything before either, but at a certain point you start to wonder, like, why am I even reading books. I guess it might help if I was at a party and chatting with a virologist and he wanted to say something interesting but there's a certain base level of knowledge I'd need in order to understand the more interesting thing? haha I don't go to parties and all my friends are unemployed graphic designers.

Carl Zimmer is not that virologist who has something interesting to say. I wasn't all that into this book. Look, Siddhartha Mukherjee is the gold standard for talking about medical shit in an engaging and vaguely understandable way, right? Carl Zimmer's nowhere close. On the scale between textbook and Mukherjee, Zimmer's pretty low down. I was bored.

Also he says to take zinc for a cold and I'm pretty sure that's bullshit.

not totally clear on to what extent this is a metaphor

He does, finally, at the end, talk about whether viruses count as "alive" or not, and I think that debate is super interesting. We've come up with a definition of "life," which like all definitions is sortof "decide what you think is alive and then describe that and there you are," so in other words it's bullshit, but anyway what it is is you have to be able to reproduce, and some other stuff, and viruses don't exactly reproduce, right? They make other peoples' cells do it for them. So does that count? What if viruses feel really bad about making us sick, and they keep having conferences to try to come up with ways to reproduce without making people sick, but maybe there's a contingent of like alt-right viruses who don't believe in sickness. This is the interesting part - saying we don't know shit about colds is not the interesting part - and there isn't enough of it. I also wanted to talk about rabies, because rabies is bananas, and he didn't. My thing with rabies is, it gets into your saliva, that makes sense, but then it makes you want to bite everyone so your saliva gets into them? That's so awesome! How does it do that? How did evolution come up with that? I don't know! I don't understand any of this!

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	Contributing Authors
	Preface
Sect. I	General Principles	1
1	Principles of Antiepileptic Drug Action	3
2	Neurophysiological Effects of Antiepileptic Drugs	23
3	Discovery and Preclinical Development of Antiepileptic Drugs	36
4	New Antiepileptic Drug Development: Medical Perspective	49
5	Clinical Development of Antiepileptic Drugs: Industry Perspective	58
6	The Development of Antiepilepsy Drugs: Regulatory Perspective	66
7	Antiepileptic Drug Monotherapy in Adults: Selection and Use in New-Onset Epilepsy	72
8	Combination Therapy and Drug Interactions	96
9	Laboratory Monitoring of Antiepileptic Drugs	103
10	Safety Monitoring of Antiepileptic Drugs	112
11	Use of Antiepileptic Drugs in Children	119
12	Antiepileptic Drug Use in Women	132
13	Epilepsy in the Elderly	149
14	Treatment of Status Epilepticus	159
15	Prevention of Epileptogenesis	169
Sect. II	Benzodiazepines	177
16	Mechanisms of Action	179
17	Chemistry, Biotransformation, and Pharmacokinetics	187
18	Clinical Efficacy and Use in Epilepsy	206
19	Adverse Effects	215
Sect. III	Carbamazepine	225
20	Mechanisms of Action	227
21	Chemistry, Biotransformation, and Pharmacokinetics	236
22	Interactions with Other Drugs	247
23	Clinical Efficacy and Use in Epilepsy	262
24	Clinical Efficacy and Use in Other Neurological Disorders	273
25	Clinical Efficacy and Use in Psychiatric Disorders	278
26	Adverse Effects	285
Sect. IV	Felbamate	299
27	Felbamate	301
Sect. V	Gabapentin	319
28	Mechanisms of Action	321
29	Chemistry, Biotransformation, Pharmacokinetics, and Interactions	335
30	Clinical Use	340
31	Clinical Efficacy and Use in Other Neurological Disorders	344
32	Clinical Efficacy and Use in Psychiatric Disorders	349
33	Adverse Effects	354
Sect. VI	Lamotrigine	361
34	Mechanisms of Action	363
35	Chemistry, Biotransformation, and Pharmacokinetics	370
36	Interactions with Other Drugs	380
37	Clinical Efficacy and Use in Epilepsy	389
38	Efficacy and Use in Nonepileptic Disorders	403
39	Adverse Effects	408
Sect. VII	Levetiracetam	417
40	Mechanisms of Action	419
41	Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions	428
42	Clinical Use	433
43	Adverse Experiences	442
Sect. VIII	Oxcarbazepine	449
44	Mechanisms of Action	451
45	Chemistry, Biotransformation, and Pharmacokinetics	459
46	Interactions with Other Drugs	466
47	Clinical Efficacy and Use in Epilepsy	470
48	Clinical Efficacy and Use in Psychiatric Disorders	476
49	Adverse Effects	479
Sect. IX	Phenobarbital and Other Barbiturates	487
50	Mechanisms of Action	489
51	Chemistry, Biotransformation, and Pharmacokinetics	496
52	Interactions with Other Drugs	504
53	Clinical Efficacy and Use in Epilepsy	514
54	Clinical Efficacy and Use in Nonepileptic Disorders	522
55	Adverse Effects	528
56	Methylphenobarbital	541
Sect. X	Phenytoin and Other Hydantoins	549
57	Mechanisms of Action	551
58	Chemistry and Biotransformation	565
59	Interactions with Other Drugs	581
60	Clinical Efficacy and Use in Epilepsy	591
61	Clinical Efficacy and Use in Other Neurological Disorders	597
62	Clinical Efficacy and Use in Psychiatric Disorders	600
63	Adverse Effects	605
64	Fosphenytoin	611
Sect. XI	Primidone	619
65	Primidone	621
Sect. XII	Succinimides	637
66	Mechanisms of Action	639
67	Ethosuximide: Chemistry, Biotransformation, Pharmacokinetics, and Drug Interactions	646
68	Clinical Efficacy and Use in Epilepsy	652
69	Adverse Effects	658
70	Methsuximide	665
Sect. XIII	Tiagabine	673
71	Mechanisms of Action	675
72	Chemistry, Biotransformation, and Pharmacokinetics	681
73	Drug Interactions	691
74	Clinical Efficacy and Use in Epilepsy	698
75	Clinical Efficacy and Use in Nonepileptic Disorders	705
76	Adverse Effects	711
Sect. XIV	Topiramate	717
77	Mechanisms of Action	719
78	Chemistry, Biotransformation, and Pharmacokinetics	727
79	Drug Interactions	735
80	Clinical Efficacy and Use in Epilepsy	740
81	Clinical Efficacy and Use in Nonepileptic Disorders	753
82	Adverse Effects	760
Sect. XV	Valproic Acid	765
83	Mechanisms of Action	767
84	Chemistry, Biotransformation, and Pharmacokinetics	780
85	Drug Interactions	801
86	Clinical Efficacy and Use in Epilepsy	808
87	Clinical Efficacy and Use in Other Neurological Disorders	818
88	Clinical Efficacy and Use in Psychiatric Disorders	828
89	Adverse Effects	837
Sect. XVI	Vigabatrin	853
90	Vigabatrin	855
Sect. XVII	Zonisamide	865
91	Mechanisms of Action	867
92	Chemistry, Biotransformation, and Pharmacokinetics	873
93	Drug Interactions	880
94	Clinical Efficacy and Use in Epilepsy	885
95	Adverse Effects	892
Sect. XVIII	Drugs in Development	899
96	Pregabalin	901
97	Rufinamide	906
98	Drugs in Early Clinical Development	913
	Subject Index	929