Evidence Base of Clinical Diagnosis Book

1 General introduction: evaluation of diagnostic procedures J. Andre Knottnerus Knottnerus, J. Andre Frank Buntinx Buntinx, Frank Chris van Weel van Weel, Chris 1

2 The architecture of diagnostic research R. Brian Haynes Haynes, R. Brian John J. You You, John J. 20

3 Assessment of the accuracy of diagnostic tests: the cross-sectional study J. Andre Knottnerus Knottnerus, J. Andre Jean W. Muris Muris, Jean W. 42

4 Diagnostic testing and prognosis: the randomized controlled trial in test evaluation research Jeroen G. Lijmer Lijmer, Jeroen G. Patrick M. M. Bossuyt Bossuyt, Patrick M. M. 63

5 The diagnostic before-after study to assess clinical impact J. Andre Knottnerus Knottnerus, J. Andre Geert-Jan Dinant Dinant, Geert-Jan Onno P. Van Schayck Van Schayck, Onno P. 83

6 Designing studies to ensure that estimates of test accuracy will travel Les M. Irwig Irwig, Les M. Patrick M. M. Bossuyt Bossuyt, Patrick M. M. Paul P. Glasziou Glasziou, Paul P. Constantine Gatsonis Gatsonis, Constantine Jeroen G. Lijmer Lijmer, Jeroen G. 96

7 Analysis of data on the accuracy of diagnostic tests J. Dik F. Habbema Habbema, J. Dik F. Rene Eijkemans Eijkemans, Rene Pieta Krijnen Krijnen, Pieta J. Andre Knottnerus Knottnerus, J. Andre 118

8 Multivariable analysis in diagnostic accuracy studies: what are the possibilities? Frank Buntinx Buntinx, Frank Bert Aertgeerts Aertgeerts, Bert Marc Aerts Aerts, Marc Rudi Bruyninckx Bruyninckx, Rudi J. Andre Knottnerus Knottnerus, J. Andre Ann van den Bruel van den Bruel, Ann Jef van den Ende van den Ende, Jef 146

9 Standards for reporting on diagnostic accuracy studies Patrick M. M. Bossuyt Bossuyt, Patrick M. M. Nynke Smidt Smidt, Nynke167

10 Guidelines for conducting systematic reviews of studies evaluating the accuracy of diagnostic tests Frank Buntinx Buntinx, Frank Bert Aertgeerts Aertgeerts, Bert Petra Macaskill Macaskill, Petra 180

11 Producing and using clinical prediction rules Tom Fahey Fahey, Tom Johan van der Lei van der Lei, Johan 213

12 Clinical problem solving and diagnostic decision making: a selective review of the cognitive research literature Alan Schwartz Schwartz, Alan Arthur S. Elstein Elstein, Arthur S. 237

13 Improving test ordering and its diagnostic cost-effectiveness in clinical practice - bridging the gap between clinical research and routine health care Ron Winkens Winkens, Ron Trudy van der Weijden van der Weijden, Trudy Hans Severens Severens, Hans Geert-Jan Dinant Dinant, Geert-Jan 256

14 Epilogue: overview of evaluation strategy and challenges J. Andre Knottnerus Knottnerus, J. Andre Ann van den Bruel van den Bruel, Ann Frank Buntinx Buntinx, Frank 273

Index 285