Rheumatoid Arthritis Book

1	Joints and Connective Tissue: The Targets of Rheumatoid Arthritis	3
2	History and Epidemiology of Rheumatoid Arthritis: How Long Has It Affected Us, and Who Is at Risk?	21
3	Immunogenetics	28
4	Is There One Cause of Rheumatoid Arthritis?	41
5	T Lymphocytes	52
6	B Lymphocytes and Rheumatoid Factor	74
7	Leukocyte Translocation from Blood to Synovium	89
8	Cytokines, Lymphokines, Growth Factors, and Chemokines	105
9	Rheumatoid Synovium: Complex, and More Than the Sum of its Parts	126
10	Cartilage and the Mechanisms for its Destruction	150
11	The Pannus-Cartilage Junction: Focus of the Destructive Process	158
12	Enzymes Responsible for Joint Destruction	168
13	Intra-articular Pressure, Blood Flow, and pH in the Rheumatoid Joint	179
14	Synovial Fluid: A Sink for Neutrophils and Inflammatory Mediators	183
15	Nitric Oxide: Messenger for Modulation of Inflammation	195
16	The Pain of Arthritis - Neuroendocrine Associations	198
17	Phospholipase A[subscript 2], Cyclo-oxygenase, Prostaglandins, and Leukotrienes	202
18	Immune Complexes, Complement, Kinins, Clot Formation, and Fibrinolysis	206
19	Clinical Features and Differential Diagnosis	215
20	Course and Complications of Established Rheumatoid Arthritis	232
21	Diagnostic Imaging in Rheumatoid Arthritis	259
22	Laboratory Assays: The Acute-Phase Response	271
23	Biochemical Markers Associated with Rheumatoid Arthritis	273
24	Assessment of Rheumatoid Arthritis	279
25	Prognosis for Patients with Rheumatoid Arthritis	305
26	General Principles of Therapy	317
27	Use of Patient Education and Physical Modalities in Early Treatment	324
28	Diet and Rheumatoid Arthritis	332
29	Nonsteroidal Anti-Inflammatory Drugs, Including Aspirin	337
30	The Role of Glucocorticoids	350
31	Second-Line Treatment	364
32	Methotrexate	379
33	Cytotoxic, Immunosuppressive, and Biologic Therapy	390
34	Combination Therapy	412
35	Antibiotics and Other Novel Therapies	415
Appendix	Cited Abstracts of the 1995 ACR National Scientific Meeting	418
	Index	421