Thrombosis and Hemorrage Book

	Preface
	Acknowledgment
	Contributors
Sect. 1	Coagulation and Fibrinolysis
1	Coagulation Cascade: An Overview	3
2	Molecular Genetics of Blood Coagulation	29
3	Regulation of Coagulation	45
4	The Tissue Factor Pathway of Coagulation	77
5	Contact Activation	105
6	Fibrin Formation and Stabilization	129
7	Fibrinolysis and Its Regulation	155
Sect. 2	Platelets
8	Regulation of Megakaryopoiesis	173
9	Platelet Turnover	195
10	Platelet Morphology	207
11	Platelet Membranes and Receptors	229
12	Mechanisms of Platelet Activation	261
Sect. 3	Vessel Wall
13	Overview of the Endothelium	295
14	The Vascular Response to Injury	307
15	Interactions of Leukocytes with the Vessel Wall	321
16	von Willebrand Factor	337
17	Interaction of Coagulation Factors with the Vessel Wall	365
18	Interaction of the Fibrinolytic System with the Vessel Wall	373
19	Endothelium-Derived Vasoactive Factors	387
20	Rheology	405
Sect. 4	Experimental Models
21	Experimental Models of Thrombosis and Thrombolysis	425
22	Genetic Models of Thrombosis and Hemorrhage	435
Sect. 5	Clinical Approach to Bleeding and Thrombosis
23	Approach to Bleeding	459
24	Approach to Thrombosis	477
25	Assessment of Arterial and Venous Thrombosis	491
26	Laboratory Methods in Hemostasis	517
Sect. 6	Quantitative Platelet Disorders
27	Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome	583
28	The Alloimmune Thrombocytopenias	599
29	Drug-Induced Thrombocytopenias	617
30	Immune Thrombocytopenic Purpura	643
31	Thrombocytosis	665
Sect. 7	Qualitative Platelet Disorders
32	Congenital Disorders of Platelet Function	683
33	Acquired Disorders of Platelet Function	707
Sect. 8	Disorders of Coagulation Factors and Fibrinolysis
34	von Willebrand Disease	729
35	Hemophilia-Factor VIII Deficiency	757
36	Other Coagulation Factor Deficiencies	773
37	Factor VIII and Other Coagulation Factor Inhibitors	803
38	Antiphospholipid Syndrome, Lupus Anticoagulants, and Anticardiolipin Antibodies	817
Sect. 9	Thrombotic Disorders
39	The Relationship between Thrombosis and Atherosclerosis	837
40	Inherited and Acquired Hypercoagulable States	863
41	Endotheliopathies: Clinical Manifestations of Endothelial Dysfunction	901
42	Interaction of Blood and Artificial Surfaces	925
Sect. 10	Other Disorders of Hemostasis
43	Vascular Purpura and Diseases of Blood Vessels	945
44	Disseminated Intravascular Coagulation	963
45	Coagulopathy of Liver Failure and Vitamin K Deficiency	987
46	Maternal Hemostasis: Coagulation Problems of Pregnancy	1005
47	Hemorrhage, Thrombosis, and Antithrombotic Therapy in Children	1027
48	Hemostatic Complications of HIV Infection	1065
49	Hemostatic Complications of Blood and Bone Marrow Transplantation	1077
50	Effects of Cardiopulmonary Bypass on Hemostasis	1091
Sect. 11	Management of Bleeding
51	Platelet Transfusion Therapy	1119
52	Plasma and Component Therapy	1135
53	NonTransfusional Modalities	1163
Sect. 12	Management of Thrombosis
54	Pharmacology of Antiplatelet Agents	1181
55	Pharmacology of Heparin and Oral Anticoagulants	1193
56	Pharmacology of Thrombolytic Agents	1215
57	New Antithrombotic Strategies	1259
58	Antithrombotic Interventions in Cerebrovascular Disease	1279
59	Antithrombotic Therapy in Cardiovascular Disease	1309
60	Anticoagulants in Atrial Fibrillation	1337
61	Prevention and Treatment of Venous Thromboembolic Disease	1351
62	Gene Therapy of Thrombotic and Hemorrhagic Disorders	1377
	Index