Essential immunology Book

	Preface
	Acknowledgements
	User guide
1	The Basis of Immunology: I - Innate Immunity
2	The Basis of Immunology: II - Specific Acquired Immunity
3	Molecules Which Recognize Antigen
	The immunoglobulins	35
	The major histocompatibility complex (MHC)	51
	The T-cell receptor	56
	The generation of diversity for antigen recognition	58
4	The Recognition of Antigen: I - Primary Interaction
5	The Recognition of Antigen: II - Detection and Application
6	The Acquired Immune Response: I - Consequences of Antigen Recognition
	Where does it all happen? - The anatomy of the immune response	105
	The activation of T-cells	115
	The activation of B-cells	120
7	The Acquired Immune Response: II - Production of Effectors
	The synthesis of humoral antibody	129
	Cell-mediated immunity has two arms	140
	Killer T-cells	147
	Memory cells	148
8	The Acquired Immune Response: III - Control
9	The Acquired Immune Response: IV - Development
	T-cell development	173
	B-cell development	183
	Unregulated development gives rise to lymphoproliferative disorders	188
	The evolution of the immune response	196
10	Immunity to Infection: I - Adversarial strategies
	Extracellular bacteria susceptible to killing by phagocytosis and complement	203
	Bacteria which grow in an intracellular habitat	208
	Immunity to viral infection	212
	Immunity to parasitic infections	216
11	Immunity to Infection: II - Prophylaxis and Immunodeficiency
	Passively acquired immunity	225
	Vaccination	226
	Primary immunodeficiency states in the human	239
	Secondary immunodeficiency	244
12	Hypersensitivity
	Type I - anaphylactic hypersensitivity	253
	Type II - antibody-dependent cytotoxic hypersensitivity	260
	Type III - immune-complex-mediated hypersensitivity	264
	Type IV - cell-mediated (delayed-type) hypersensitivity	270
	Type V - stimulatory hypersensitivity	272
	'Innate' hypersensitivity reactions	272
13	Transplantation
	Graft rejection	277
	The prevention of graft rejection	282
	Clinical experience in grafting	291
	Association of HLA type with disease	293
	The immunological relationship of mother and fetus	296
	Is the cancer cell like an allograft?	296
14	Autoimmune Diseases: I - Scope and Aetiology
	Aetiology of autoimmune responses	245
15	Autoimmune Diseases: II - Pathogenesis, Diagnosis and Treatment
	Pathogenic mechanisms in autoimmune disease	325
	Diagnostic value of autoantibody tests	340
	Treatment of autoimmune disorders	340
	Index	347