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Foreword | ||
Dedication | ||
Acknowledgements | ||
Introduction | 1 | |
Ch. 1 | The microscope and the cell | 9 |
The cell theory | 10 | |
The problem of generation | 12 | |
The problem of embryonic development | 15 | |
The two versions of the cell theory | 17 | |
Mechanism | 19 | |
The chemical machine | 21 | |
The computer model | 24 | |
The autopoietic cell | 27 | |
The epigenetic cell | 29 | |
Ch. 2 | Theories of evolution | 33 |
Traditional biology | 34 | |
Lamarck's contribution | 36 | |
Darwin's bet | 38 | |
Natural selection | 40 | |
Organs of extreme perfection | 41 | |
Common descent | 44 | |
The second mechanism of evolution | 49 | |
The Modern Synthesis | 51 | |
Molecular evolution | 54 | |
The third mechanism of evolution | 57 | |
Macroevolution | 60 | |
Where is biology going to? | 63 | |
Ch. 3 | A new model for biology | 67 |
The logic of embryonic development | 67 | |
Reconstructions from incomplete projections | 69 | |
A memory-building approach | 71 | |
The algebraic method | 75 | |
The theoretical limit | 79 | |
ART: an iterative algebraic method | 80 | |
The memory matrix | 82 | |
Density modulation | 84 | |
MRM: the family of memory algorithms | 86 | |
The two general principles of MRM | 89 | |
Ch. 4 | Organic codes and organic memories | 93 |
The characteristics of codes | 93 | |
The organic codes' fingerprints | 96 | |
The bridge between genes and organism | 99 | |
The splicing codes | 101 | |
The signal transduction codes | 105 | |
Contextual information | 111 | |
Determination and cell memory | 112 | |
The other face of pattern | 114 | |
Hints from developing neurons | 117 | |
The key structures of embryonic development | 119 | |
Ch. 5 | The origin of life | 121 |
The primitive Earth | 122 | |
Chemical evolution | 127 | |
Postchemical evolution | 129 | |
The metabolism paradigm | 131 | |
The replication paradigm | 134 | |
The RNA world | 138 | |
Replication catastrophes | 140 | |
Eigen's paradox | 142 | |
The ribotype theory | 145 | |
The genetic code | 148 | |
Evolution of the code | 155 | |
The ribotype metaphor | 157 | |
Copymakers and codemakers | 159 | |
The handicapped replicator | 161 | |
Ch. 6 | Prokaryotes and eukaryotes | 163 |
The potassium world | 164 | |
Two forms of life | 166 | |
Three primary kingdoms | 168 | |
The last common ancestor | 173 | |
The origins of bacteria | 175 | |
The cytoskeleton | 178 | |
The compartments | 180 | |
Chromosomes | 182 | |
The seven kingdoms | 185 | |
Three thousand million years | 187 | |
Ch. 7 | The Cambrian explosion | 191 |
The fossil record | 192 | |
The experimental data | 193 | |
Body plans and phylotypic stages | 196 | |
The traditional explanations | 201 | |
The Cambrian singularity | 202 | |
The stumbling-block | 203 | |
The reconstruction model | 204 | |
Multicellular structures | 206 | |
Biological memories | 209 | |
A new model of the Cambrian explosion | 210 | |
The conservation of the phylotypic stage | 213 | |
Ch. 8 | Semantic biology | 217 |
The semantic theory of the cell | 219 | |
The semantic theory of embryonic development | 221 | |
The mind problem | 224 | |
The semantic theory of mental development | 226 | |
Artifacts and natural selection | 228 | |
The semantic theory of evolution | 229 | |
About organic codes | 234 | |
The language model | 236 | |
The Individuality Thesis | 237 | |
The development of semantic biology | 240 | |
Ch. 9 | A brief summary | 243 |
The first principle | 244 | |
The second principle | 245 | |
The third principle | 246 | |
The fourth principle | 247 | |
The first model | 248 | |
The second model | 249 | |
The third model | 250 | |
The fourth model | 251 | |
Conclusion | 253 | |
App | Definitions of life | 255 |
Afterword | 265 | |
References | 279 | |
Index | 295 |
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