Cerebrovascular Disease: 22nd Princeton Conference Book

	List of contributors
	Preface
	Acknowledgments
1	Zinc toxicity in the ischemic brain	3
2	Central nervous system ischemia: diversity among the caspases	9
3	Peroxynitrite and injury to the vasculature and central nervous system in stroke and neurodegeneration	23
4	Interaction between inducible nitric oxide and cyclooxygenase-2 in ischemic brain injury	47
5	Mechanisms of ischemic tolerance	58
6	Clinically tolerated NMDA receptor antagonists and newly cloned NMDA receptor subunits that mimic them	72
7	Cell death programs in neural development and disease	81
8	Apoptotic gene expression in brain ischemia and ischemic tolerance	87
9	Cellular mechanisms of white matter ischemia: what can we learn from culture models?	95
10	Astrocytes in ischemic stroke	113
11	Aquaporin-4 water channels and brain edema	125
12	Neuroprotection with tetracyclines in brain ischemia models	135
13	Spreading depression: a teleological means for self-protection from brain ischemia	142
14	The role of matrix metalloproteinases and urokinase in blood-brain barrier damage with thrombolysis	161
15	Does brain nitric oxide generation influence tissue oxygenation after severe human subarachnoid hemorrhage?	172
16	Tissue plasminogen activator and hemorrhagic brain injury	181
17	Dynamics of infarct evolution after permanent and transient focal brain ischemia in mice	192
18	Inflammation and stroke: benefits or harm?	213
19	TNF-[alpha] and ceramide are involved in the mediation of neuronal tolerance to brain ischemia	226
20	Sites and mechanisms of IL-1 action in ischemic and excitotoxic brain damage	237
21	Protease generation, inflammation and cerebral microvascular activation	247
22	Adenoviral vectors for gene therapy in stroke	261
23	Gene transfer of glial cell line-derived neurotrophic factor prevents ischemic brain injury	269
24	Vasomotor effects of nitric oxide, superoxide dismutases and calcitonin gene-related peptide	284
25	Transplantation of neural stem cells: cellular and gene therapy in pediatric hypoxic-ischemic brain injury	299
26	Neural plasticity after cerebral ischemia	317
27	Environmental effects on recovery after stroke	328
28	Magnetic resonance imaging in stroke trials	339
29	Disappearing deficits and disappearing lesions: diffusion/perfusion MRI in transient ischemic attack and intra-arterial thrombolysis	353
30	Diffusion and perfusion magnetic resonance imaging in the evaluation of acute ischemic stroke	371
31	Early recanalization in acute ischemic stroke saves tissue at risk defined by stroke magnetic resonance imaging	381
32	Vascular factors in Alzheimer's disease	393
33	Beyond neuroprotection: the protection of axons and oligodendrocytes in cerebral ischemia	404
34	Combining neuroprotection with thrombolysis: how to translate laboratory success to our clinical trials	416
35	Prospects for improved neuroprotection trials in stroke	430
36	Basic research and stroke therapeutics: what have we learned?	444
	Index	452