Pediatric Traumatic Brain Injury: New Frontiers in Clinical and Translational Research Book

List of contributors vi

Acknowledgments viii

Introduction: Pediatric traumatic brain injury: New frontiers in clinical and translational research Vicki Anderson Keith Owen Yeates 1

1 Biomechanics of pediatric TBI Susan S. Margulies Brittany Coats 7

2 Neurobiology of TBI sustained during development Mayumi L. Prins Christopher C. Giza David A. Hovda 9

3 Using serum biomarkers to diagnose, assess, treat, and predict outcome after pediatric TBI Rachel P. Berger Ronald L. Hayes Kevin K.W. Wang Patrick Kochanek 36

4 Clinical trials for pediatric TBI P. David Adelson 54

5 Advanced neuroimaging techniques in children with traumatic brain injury Stephen Ashwal Karen A. Tong Andre Obenaus Barbara A. Holshouser 68

6 Neurobehavioral outcomes of pediatric mild traumatic brain injury Michael W. Kirkwood Keith Owen Yeates 94

7 Very long-term neuropsychological and behavioral consequences of mild and complicated mild TBI: increased impact of pediatric versus adult TBI Erik Hessen 118

8 Neurobehavioral outcomes of pediatric traumatic brain injury H. Gerry Taylor 145

9 Neuropsychological rehabilitation in children with traumatic brain injuries Ingrid van't Hooft 169

10 Psychosocial interventions Shari L. Wade 179

11 Pediatric TBI: challenges for treatment and rehabilitation Cathy Catroppa Vicki Anderson 192

12 Integrating multidisciplinary research for translation from the laboratory to the clinic Bryan Kolb Robbin Gibb 207

Index 225