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Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology Book

Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology
Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology, At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid, Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology has a rating of 4 stars
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Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology, At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid, Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology
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  • Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology
  • Written by author William M. Pardridge
  • Published by Cambridge University Press, December 2006
  • At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid
  • A comprehensive introduction to the blood-brain barrier and methodology of its study from international authorities.
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Authors

List of contributors
1Blood brain barrier methodology and biology1
2The carotid artery single injection technique11
3Development of the Brain Efflux Index (BEI) method and its application to the blood-brain barrier efflux transport study24
4In situ brain perfusion32
5Intravenous injection / pharmacokinetics41
6Isolated brain capillaries: an in vitro model of blood brain barrier research49
7Isolation and behavior of plasma membrane vesicles made from cerebral capillary endothelial cells62
8Patch clamp technique with isolated brain microvessel membranes71
9Tissue culture of brain endothelial cells - induction of blood-brain barrier properties by brain factors79
10Brain microvessel endothelial cell culture systems86
11Intracerebral microdialysis94
12Blood-brain barrier permeability measured with histochemistry113
13Measuring local cerebral capillary permeability-surface area products by quantitative autoradiography122
14Measurement of blood-brain barrier permeability in humans using indicator diffusion133
15Measurement of blood-brain barrier permeability in humans with positron emission tomography140
16Magnetic resonance imaging of blood-brain barrier permeability147
17Molecular biology of brain capillaries151
18Biology of the blood-brain glucose transporter165
19Glucose transporters in mammalian brain development175
20Blood-brain barrier amino acid transport188
21P-glycoprotein, a guardian of the brain198
22Blood-brain barrier ion transport207
23Ion channels in endothelial cells214
24Interactions of lipoproteins with the blood-brain barrier221
25Fatty acid and lipid intermediate transport227
26Blood-brain barrier transport of drugs238
27The blood-CSF barrier and the choroid plexus251
28Arachnoid membrane, subarachnoid CSF and pia-glia259
29Circumventricular organs of the brain270
30Transport in the developing brain277
31Regulation of brain endothelial cell tight junction permeability293
32Chemotherapy and chemosensitization301
33Lipid composition of brain microvessels308
34Brain microvessel antigens314
35Molecular dissection of tight junctions: occludin and ZO-l322
36Phosphatidylinositol pathways330
37Nitric oxide and endothelin at the blood-brain barrier338
38Role of intracellular calcium in regulation of brain endothelial permeability345
39Cytokines and the blood-brain barrier354
40Blood-brain barrier and monoamines, revisited362
41Cerebral amyloid angiopathy379
42Brain microvasculature in multiple sclerosis386
43Hemostasis and the blood brain barrier401
44Microvascular pathology in cerebrovascular ischemia409
45HIV infection and the blood-brain barrier419
46Hypertension427
47The blood-brain barrier in brain tumours434
48The pathophysiology of blood-brain barrier dysfunction due to traumatic brain injury441
49Cerebral malaria and the brain microvasculature454
50Molecular basis of tissue tropism of bacterial meningitis462


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Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology, At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid, Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology

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Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology, At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid, Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology

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Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology, At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. This introduction for both researchers and clinicians is intended to aid, Introduction to the Blood-Brain Barrier: Methodology, Biology and Pathology

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