The BMT Data Book Book

List of contributors ix

Foreword xi

Preface xiii

Acknowledgments xvi

Section 1 Basic science 1

1 Basic science Reinhold Munker Gary Brooke Kerry Atkinson 3

Section 2 Hematologic malignancies 21

2 Therapeutic decision making in BMT/SCT for acute myeloid leukemia Reinhold Munker Ramiro Garzon Kerry Atkinson 23

3 Therapeutic decision making in BMT/SCT for acute lymphoblastic leukemia Reinhold Munker Vishwas Sakhalkar Hillard M. Lazarus Kerry Atkinson 41

4 Therapeutic decision making in BMT/SCT for chronic myeloid leukemia and other myeloproliferative syndromes Reinhold Munker Hillard M. Lazarus Kerry Atkinson 57

5 Therapeutic decision making in BMT/SCT for chronic lymphatic leukemia Reinhold Munker Hillard M. Lazarus Kerry Atkinson 71

6 Therapeutic decision making in BMT/SCT for myelodysplasia Reinhold Munker Kerry Atkinson 85

7 Therapeutic decision making in BMT/SCT for non-Hodgkin Lymphoma Reinhold Munker Hillard M. Lazarus Kerry Atkinson 99

8 Therapeutic decision making in BMT/SCT for Hodgkin lymphoma Reinhold Munker Hillard M. Lazarus Kerry Atkinson 127

9 Therapeutic decision making in hematopoietic stem cell transplantation for multiple myeloma Oscar F. Ballester Reinhold Munker Hillard M. Lazarus Kerry Atkinson 139

10 Therapeutic decision making in BMT/SCT for amyloidosis Reinhold Munker Hillard M. Lazarus Kerry Atkinson 157

Section 3 Solid tumors 163

11 Therapeutic decision making in stem cell transplantation for breast cancer Naoto T. Ueno Reinhold Munker Kerry Atkinson 165

12 Therapeutic decision making in BMT/SCT for nonseminomatous germ cell tumor of testis (NSGCT) Reinhold Munker Hillard M. Lazarus Kerry Atkinson 169

13 Therapeutic decisionmaking in BMT/SCT for renal cell cancer Richard W. Childs Reinhold Munker 177

14 Therapeutic decision making in BMT/SCT for soft tissue sarcomas Reinhold Munker Vishwas Sakhalkar Hillard M. Lazarus Kerry Atkinson 189

Section 4 Nonmalignant disorders 195

15 Therapeutic decision making in BMT/SCT for severe aplastic anemia Reinhold Munker Anna Locasciulli Kerry Atkinson 197

16 Therapeutic decision making in BMT/SCT for congenital immunodeficiencies Vishwas Sakhalkar Reinhold Munker Kerry Atkinson 205

17 Therapeutic decision making in BMT/SCT for hemoglobinopathies Shalini Shenoy Reinhold Munker Kerry Atkinson 215

18 Therapeutic decision making in BMT/SCT for autoimmune disorders Reinhold Munker 227

Section 5 Practical aspects and procedures 233

19 Practical aspects and procedures, including conditioning protocols and haploidentical transplantation Reinhold Munker Hillard M. Lazarus Kerry Atkinson 235

20 Umbilical cord blood as alternative allogeneic graft source: clinical banking and transplant outcomes R. Patrick Weitzel Mary J. Laughlin 301

Section 6 Complications 311

21 Pathobiology of graft-versus-host disease Pavan Reddy 313

22 Diagnosis and treatment of graft-versus-host-disease Daniel R. Couriel 331

23 Management and prophylaxis of infections after BMT/SCT Alison G. Freifeld Reinhold Munker Kerry Atkinson 357

24 Organ-related and miscellaneous complications Reinhold Munker Amanda Sun Hillard M. Lazarus Kerry Atkinson 379

Section 7 The BMT/SCT pharmacopoeia 429

25 The BMT/SCT pharmacopoeia Reinhold Munker Kerry Atkinson 431

Section 8 HLA-testing and laboratory medicine 493

26 HLA-testing and laboratory medicine Nicholas R. DiPaola Reinhold Munker Kerry Atkinson 495

Appendix 511

Index 515