Catalysts For Fine Chemical Sy, Vol. 1 Book

1	Considerations of industrial fine chemical synthesis	1
2	Alkylation and allylation adjacent to a carbonyl group	13
2.1	The RuH[subscript 2](CO)(PPh[subscript 3])[subscript 3]-catalysed alkylation, alkenylation and arylation of aromatic ketones via carbon-hydrogen bond cleavage	14
2.2	Catalytic, asymmetric synthesis of [alpha],[alpha]-disubstituted amino acids using a chiral copper-salen complex as a phase transfer catalyst	21
2.3	Asymmetric phase-transfer catalysed alkylation of glycine imines using cinchona alkaloid derived quaternary ammonium salts	27
3	Asymmetric alkylation or amination of allylic esters	35
3.1	Synthesis and application in palladium-catalysed asymmetric allylic substitution of enantiopure cyclic [beta]-iminophosphine ligands	36
3.2	(9H,9'H,10H,10'H,11H,11H',13H,13'H,14H,14'H,15H,15'H -perfluorotricosane-12,12'-diyl)bis[(4s)-4-phenyl-2-oxazoline as a ligand for asymmetric palladium-catalysed alkylation of allylic acetates in fluorous media	40
3.3	Facile synthesis of new axially chiral diphosphine complexes for asymmetric catalysis	47
3.4	Chiral ferrocenyl-imino phosphines as ligands for palladium-catalysed enantioselective allylic alkylations	51
4	Suzuki coupling reactions	59
4.1	Palladium-catalysed borylation and Suzuki coupling (BSC) to obtain [beta]-benzo[b]thienyldehydroamino acid derivatives	60
4.2	Palladium-catalysed cross-coupling reactions of 4-tosylcoumarins and arylboronic acids : synthesis of 4-arylcoumarin compounds	64
4.3	Cyclopropyl arenes, alkynes and alkenes from the in situ generation of B-cyclopropyl-9-BBN and the Suzuki-Miyaura coupling of aryl, alkynyl and alkenyl bromides	67
4.4	One-pot synthesis of unsymmetrical 1,3-dienes through palladium-catalysed sequential borylation of a vinyl electrophile by a diboron and cross-coupling with a distinct vinyl electrophile	70
4.5	Pd(OAc)[subscript 2]/2-Aryl oxazoline catalysed Suzuki coupling reactions of aryl bromides and boronic acids	74
4.6	Palladium-catalysed reactions of haloaryl phosphine oxides : modular routes to functionalised ligands	77
4.7	Bulky electron rich phosphino-amines as ligands for the Suzuki coupling reaction of aryl chlorides	81
4.8	Arylation of ketones, aryl amination and Suzuki-Miyaura cross coupling using a well-defined palladium catalyst bearing an N-heterocyclic carbene ligand	86
5	Heck coupling reactions	91
5.1	Palladium-catalysed multiple and asymmetric arylations of vinyl ethers carrying co-ordinating nitrogen auxiliaries : synthesis of arylated ketones and aldehydes	92
5.2	Palladium-catalysed highly regioselective arylation of electron-rich olefins	100
5.3	1-[4-(S)-tert-Butyl-2-oxazolin-2-yl]-2-(S)-(diphenylphosphino) ferrocene as a ligand for the palladium-catalysed intermolecular asymmetric Heck reaction of 2,3-dihydrofuran	104
6	Sonogashira coupling reactions	113
6.1	Nonpolar biphasic catalysis : Suzuki- and Sonogashira coupling reactions	113
6.2	Polystyrene-supported soluble palladacycle catalyst as recyclable catalyst for Heck, Suzuki and Sonogashira reactions	116
7	Cross-coupling reactions	127
7.1	Cross-coupling reaction of alkyl halides with Grignard reagents in the presence of 1,3-butadiene catalysed by nickel, palladium, or copper	128
7.2	Triorganoindium compounds as efficient reagents for palladium-catalysed cross-coupling reactions with aryl and vinyl electrophiles	133
7.3	Cross-coupling reactions catalysed by heterogeneous nickel-on-charcoal	138
7.4	Carbon-carbon bond formation using arylboron reagents with rhodium(I) catalysts in aqueous media	147
8	Regioselective or asymmetric 1,2-addition to aldehydes	155
8.1	Development of a highly regioselective metal-mediated allylation reaction in aqueous media	156
8.2	Boronic acids as aryl source for the catalysed enantioselective aryl transfer to aldehydes	161
8.3	Jacobsen's Salen as a chiral ligand for the chromium-catalysed addition of 3-chloro-propenyl pivalate to aldehydes : a catalytic asymmetric entry to syn-akl-1-ene-3,4-diols	164
9	Olefin metathesis reactions	169
9.1	Highly active ruthenium (pre)catalysts for metathesis reactions	169
9.2	A highly active and readily recyclable olefin metathesis catalyst	174
9.3	Stereoselective synthesis of L-733,060	178
10	Cyclisation reactions	181
10.1	Molecular sieves as promoters for the catalytic Pauson-Khand reaction	182
10.2	Palladium(II)-catalysed cyclization of alkynes with aldehydes, ketones or nitriles initiated by acetoxypalladation of alkynes	185
10.3	Rhodium(I)-catalysed intramolecular alder-ene reaction and syntheses of functionalised [alpha]-methylene-[gamma]-butyrolactones and cyclopentanones	190
10.4	Rhodium-catalysed [2+2+2] cyclotrimerisation in an aqueous-organic biphasic system	193
10.5	Titanocene-catalysed transannular cyclisation of epoxygerm-acrolides : enantiospecific synthesis of eudesmanolides	196
11	Asymmetric aldol and Michael reactions	201
11.1	Direct catalytic asymmetric aldol reaction of a [alpha]-hydroxyketone promoted by an Et[subscript 2]Zn/linked-BINOL complex	202
11.2	Highly enantioselective direct aldol reaction catalysed by a novel small organic molecule	208
11.3	Direct catalytic asymmetric Michael reaction of [alpha]-hydroxyketone promoted by Et[subscript 2]Zn/linked-BINOL complex	210
11.4	Catalytic enantioselective Michael reaction catalysed by well-defined chiral ruthenium-amido complexes	216
12	Stereoselective hydroformylation, carbonylation and carboxylation reactions	225
12.1	Ortho-diphenylphosphanylbenzoyl-(o-DPPB) directed diastereoselective hydroformylation of allylic alcohols	226
12.2	The synthesis and application of ESPHOS : a new diphosphorus ligand for the hydroformylation of vinyl acetate	230
12.3	Platinum-catalysed asymmetric hydroformylation of styrene	238
12.4	Phosphine-free dimeric palladium (II) complex for the carbonylation of aryl iodides	244
12.5	Carboxylation of pyrrole to pyrrole-2-carboxylate by cells of Bacillus megaterium in supercritical carbon dioxide	247