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| Contributors | ||
| Preface | ||
| 1 | Cloning and Structure: Function Analysis of the Mouse mdr Gene Family | 5 |
| 2 | Functional and Molecular Characterization of the Human Multidrug Transporter | 29 |
| 3 | Regulation of MDR Genes | 39 |
| 4 | Cytogenetic Manifestations of Multidrug Resistance | 49 |
| 5 | Chromosomal and Extrachromosomal Localization of Human MDR Genes | 73 |
| 6 | MRP, Mode of Action and Role in MDR | 95 |
| 7 | Role of LRP/Major Vault Protein in Multidrug Resistance | |
| 8 | DNA Topoisomerase I Inhibitors and Multidrug Resistance | 119 |
| 9 | The Role of Topoisomerase II in Multidrug Resistance | 137 |
| 10 | Glutathione and Glutathione-associated Enzymes in Multidrug Resistance | 151 |
| 11 | Oncogenes and Tumor Suppressor Genes in Multidrug Resistance | 177 |
| 12 | Drug Sensitivity Genes: Identification and Analysis Using the Genetic Suppressor Element Approach | 193 |
| 13 | Changes in Membrane Ionic Conductances Associated with Multidrug Resistance | 219 |
| 14 | Identification and Characterization of the Drug-binding Sites of P-glycoprotein | 231 |
| 15 | Phosphorylation of Proteins Involved in Multidrug Resistance | 251 |
| 16 | Protein Kinase C and its Isozymes in Multidrug Resistance | 263 |
| 17 | Non-PKC Kinases and Multidrug Resistance | 273 |
| 18 | P-glycoprotein Expression in Normal Human Tissues | 285 |
| 19 | P-glycoprotein in the Normal Hematopoietic Progenitors and Cells of the Immune System | 293 |
| 20 | Role of P-glycoprotein in the Transport of Hormones and Peptides | 303 |
| 21 | Role of P-glycoprotein in the Blood-Brain Barrier | 321 |
| 22 | Transport of P-glycoprotein-modifying Agents by P-glycoprotein | 331 |
| 23 | Mice with Disrupted P-glycoprotein Genes | 345 |
| 24 | Molecular Pharmacology of Reversal of Multidrug Resistance and its Clinical Implications | 361 |
| 25 | Multidrug Resistance-reversing Agents for Potential Clinical Use | 375 |
| 26 | Cyclosporins and Related Fungal Products in the Reversal of P-glycoprotein-mediated Multidrug Resistance | 385 |
| 27 | Oligonucleotide Modulation of Multidrug Resistance Gene Expression | 413 |
| 28 | Application of the MDR1 Gene for Human Gene Therapy | 435 |
| 29 | Reversal of MDR in Acute Leukemia and Non-Hodgkin's Lymphoma | 453 |
| 30 | Prognostic Significance and Reversal of MDR in Multiple Myeloma | 463 |
| 31 | Reversal of MDR in Solid Tumors | 473 |
| Index | 493 |
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| $99.99 | Digital |
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