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P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198 Book

P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198
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P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198, Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws tog, P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198
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  • P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198
  • Written by author Derek J. Chadwick, Jamie A. Goode, CIBA Foundation Staff
  • Published by Wiley-Blackwell, 1996/05/29
  • Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws tog
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P2 purinoceptors: historical perspective and classification 1
The diadenosine polyphosphate receptors: P2D purinoceptors 35
P2T purinoceptors: ADP receptors on platelets 53
P2Z purinoceptors 71
P2X receptors: a third major class of ligand-gated ion channels 91
P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes 110
Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal transduction mechanisms 130
Trophic roles of P2 purinoceptors in central nervous system astroglial cells 142
Transduction mechanisms of P2Z purinoceptors 149
The diverse series of recombinant P2Y purinoceptors 166
General discussion I: Molecular modelling of P2Y purinoceptors 189
P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis 193
Functional properties of native and cloned P2X receptors 208
ATP as a co-transmitter with noradrenaline in sympathetic nerves - function and fate 223
ATP release and its prejunctional modulation 239
General discussion II: Distribution of purinoceptors 260
General discussion II: ATP as a neurotransmitter 261
Involvement of distinct receptors in the actions of extracellular uridine nucleotides 266
Features of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell? 278
P2 purinoceptors in the immune system 290
General discussion III: Purinoceptors and the pancreas 306
Challenges in developing P2 purinoceptor-based therapeutics 309
Summing-up 322
Index of contributors 324
Subject index 326


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P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198, Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws tog, P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198

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P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198, Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws tog, P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198

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P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198, Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws tog, P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198

P2 Purionoceptors : Localization, Function and Transduction Mechanisms -No. 198

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