The Organic Chemistry of Drug Synthesis, Vol. 4 Book

Preface     xi
Open-Chain Compounds     1
Peptidomimetic Compounds     2
Antiviral Protease Inhibitors     2
Human Immunodeficiency Virus     2
Human Rhinovirus j     9
Miscellaneous Peptidomimetic Compounds     11
References     19
Alicyclic Compounds     21
Monocyclic Compounds     21
Prostaglandins     21
Antiviral Agents     25
Miscellaneous Monocyclic Compounds     29
Polycyclic Compounds: Steroids     31
19-Nor Steroids     31
Corticosteroid Related Compounds     34
Polycyclic Compounds /     38
References     40
Monocyclic Aromatic Compounds     43
Arylcarbonyl Derivatives     43
Biphenyls     47
Compounds Related to Aniline     50
Compounds Related to Arylsulfonic Acids     53
Diarylmethanes     58
Miscellaneous Monocyclic Aromatic Compounds     60
References     67
Carbocyclic Compounds Fused to a Benzene Ring     69
Indenes     69
Naphthalenes     73
Tetrahydronaphthalenes     74
Other benzofused carbocyclic compounds     79
References     81
Five-Membered Heterocycles     83
Compounds with One Heteroatom     83
Compounds with Two Heteroatoms     91
Oxazole and Isoxazoles     91
Imidazoles and a Pyrrazole     94
Thiazoles     99
Triazoles     103
Tetrazoles     109
References     112
Six-Membered Heterocycles     115
Compounds with One Heteroatom     115
Pyridines     115
Reduced Pyridines     117
Miscellaneous     119
Compounds with Two Heteroatoms     121
Pyrimidines     121
Miscellaneous Six-Membered Heterocycles     133
References     136
Five-Membered Heterocycles Fused to One Benzene Ring     139
Compounds with One Heteroatom     139
Benzofurans     139
Indoles     141
Indolones     148
Miscellaneous Compounds with One Heteroatom     153
Five-Membered Rings with Two Heterocyclic Atoms     156
Benzimidazoles     156
Miscellaneous Compounds      158
References     160
Six-Membered Heterocycles Fused to One Benzene Ring     163
Compounds with One Heteroatom     163
Benzopyrans     163
Quinolines and Their Derivatives     167
Quinolone Antibacterial Agents     172
Compounds with Two Heteroatoms     176
Benzoxazines     176
Quinazolines     178
Miscellaneous Benzo-Fused Heterocycles     184
References     186
Bicyclic Fused Heterocycles     189
Compounds with Five-Membered Rings Fused to Six-Membered Rings     189
Compounds with Two Heteroatoms     189
Compounds with Three Heteroatoms     191
Compounds with Four Heteroatoms     195
Compounds with Two Fused Six-Membered Rings     208
Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams     213
References     215
Polycyclic Fused Heterocycles     217
Compounds with Three Fused Rings     217
Compounds with Four Fused Rings     228
Compounds with Five or More Fused Rings: Camptothecins     230
References     232
Subject Index     233
Cross Index of Biological Activity      241
Cumulative Index     245