Tandem Organic Reactions Book

	Preface
1	Introduction	1
2	Aldol Condensation	3
2.1	Michael - Aldol Tandems	4
2.2	Claisen - Aldol and Multiple Aldol Condensations	18
2.3	Retro-Aldol - Aldol Tandems	22
2.4	Mannich - Aldol Tandems	28
2.5	Rearrangement - Aldol Tandems	29
2.6	Aldol-Type Reactions in Tandem with Other Processes	31
3	Michael Reactions	33
3.1	Michael Reactions Initiated by Other Reactions	34
3.2	Double Michael Reactions	44
3.3	Reflexive Michael Reactions	50
4	Tandem Vicinal Difunctionalization of Alkenes and Alkynes	57
4.1	Michael Reaction/Electrophilation	57
4.2	vic-Difunctionalization of Temporarily Activated Alkenes	68
4.3	Pauson - Khand Cyclization and Dotz Reaction	70
4.4	Intramolecular Metallo - Ene Reactions and Related CC Bond Formation Processes	76
4.5	Cationic Polyene Cyclizations	82
4.6	Miscellaneous vic-Dialkylations	86
5	Dieckmann and Claisen Cyclizations	88
5.1	Michael - Dieckmann and Michael - Claisen Reaction Tandems	89
5.2	Alkylation - Dieckmann and Related Tandem Reactions	94
5.3	Tandem Reactions Terminated by Claisen Condensation	97
6	Mannich Reaction	100
6.1	Schiff Condensation - Mannich Cyclization	100
6.2	Manifold Mannich Reactions	106
6.3	Alkylation or Acylation - Mannich Cyclization	109
6.4	Retro - Mannich Fragmentation - Mannich Cyclization	117
6.5	Mannich Cyclization Following Oxidation or Reduction	122
6.6	Cationic Aza-Cope Rearrangement - Mannich Cyclization and Others	124
7	Diels - Alder Reactions	131
7.1	Elimination/Diels - Alder Reaction Tandems	131
7.2	Retro-Diels - Alder/Diels - Alder Reactions	144
7.3	Electrocyclic/Diels - Alder Reactions	150
7.4	Diels - Alder Reactions Preceded by Other Pericyclic Reactions	163
7.5	Acylation/Diels - Alder Reaction Tandems	176
7.6	Oxidation or Reduction Initiated Diels - Alder Reactions	178
7.7	Intramolecularization	182
7.8	Assorted Triggers for the Diels - Alder Reaction	188
8	Other Cycloadditions	202
8.1	[2 + 2]-Cycloadditions	202
8.2	[2 + 2 + 2]-Cycloadditions	205
8.3	Formation of Five-Membered Rings by Concerted Cycloadditions	209
8.4	Higher-Order Cycloadditions	215
8.5	1,3-Dipolar Cycloadditions	221
9	Retro-Diels - Alder and Cheletropic Reactions	231
9.1	Diels - Alder/Retro-Diels - Alder Reaction Tandems	231
9.2	Retro-Diels - Alder Reactions Following Other Processes	250
9.3	Some Other Cheletropic Reactions	257
10	Electrocyclic Reactions	259
10.1	Electrocyclic Reaction Cascades	259
10.2	Cycloaddition or Cycloreversion/Electrocyclic Reaction Tandems	269
10.3	Rearrangement - Electrocyclic Reaction Tandems	275
10.4	Electrocyclic Reactions Induced by Enolization, Elimination, Condensation, or Other Processes	281
11	Ene, Retro-Ene, and Some Other Thermal Reactions	297
11.1	Ene Reactions	297
11.2	Retro-Ene Reactions	303
11.3	Vinylcyclopropane-to-Cyclopentene Rearrangements	306
12	Sigmatropic Rearrangements	308
12.1	[1, n]-Sigmatropic Rearrangements	308
12.2	[3.3]-Sigmatropic Rearrangements	320
13	Rearrangements and Fragmentations	361
13.1	Rearrangements	361
13.2	Fragmentation Reactions	377
14	Free Radical Reactions	398
14.1	Vicinal CC Bond Formations	399
14.2	1,3-Diyl Cycloadditions	408
14.3	Addition - Fragmentation Tandems	409
14.4	Reactions of Carbinyl Radicals Adjacent to a Small Ring	412
14.5	Miscellaneous Radical Reaction Tandems	413
15	Miscellaneous Tandem Reactions	416
15.1	Wittig and Related Reactions	416
15.2	Electrophilations	426
15.3	Eliminations and Ring Openings	442
15.4	Stitching of Alkenes and Alkynes	445
15.5	Tandem Reactions Involving Oxidoreductions	447
	References	449
	Index	493