Organic Synthesis: The Disconnection Approach Book

1 The Disconnection Approach

2 Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds

3 Strategy I: The Order of Events

4 One-Group C-X Disconnections

5 Strategy II: Chemoselectivity

6 Two-Group C-X Disconnections

7 Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy

8 Amine Synthesis

9 Strategy IV: Protecting Groups

10 One Group C-C Disconnections I: Alcohols

11 General Strategy A: Choosing a Disconnection

12 Strategy V: Stereoselectivity A

13 One Group C-C Disconnections II: Carbonyl Compounds

14 Strategy VI: Regioselectivity

15 Alkene Synthesis

16 Strategy VII: Use of Acetylenes (Alkynes)

17 Two-Group C-C Disconnections I: Diels-Alder Reactions

18 Strategy VIII: Introduction to Carbonyl Condensations

19 Two-Group C-C Disconnections II: 1,3-Difunctionalised Compounds

20 Strategy IX: Control in Carbonyl Condensations

21 Two-Group C-C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation

22 Strategy X: Aliphatic Nitro Compounds in Synthesis

23 Two-Group Disconnections IV: 1,2-Difunctionalised Compounds

24 Strategy XI: Radical Reactions in Synthesis

25 Two-Group Disconnections V: 1,4-Difunctionalised Compounds

26 Strategy XII: Reconnection

27 Two-Group C-C Disconnections VI: 1,6-diCarbonyl Compounds

28 General Strategy B: Strategy of Carbonyl Disconnections

29 Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles

30 Three-Membered Rings

31 Strategy XIV: Rearrangements in Synthesis

32 Four-Membered Rings: Photochemistry inSynthesis

33 Strategy XV: The Use of Ketenes in Synthesis

34 Five-Membered Rings

35 Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings

36 Six-Membered Rings

37 General Strategy C: Strategy of Ring Synthesis

38 Strategy XVII: Stereoselectivity B

39 Aromatic Heterocycles

40 General Strategy D: Advanced Strategy

Index