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Chiral Drugs: Chemistry and Biological Action Book

Chiral Drugs: Chemistry and Biological Action
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Chiral Drugs: Chemistry and Biological Action, An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and , Chiral Drugs: Chemistry and Biological Action
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  • Chiral Drugs: Chemistry and Biological Action
  • Written by author Lin, Guo-Qiang, You, Qi-Dong, Cheng, Jie-Fei
  • Published by Wiley, John & Sons, Incorporated, 9/21/2011
  • An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and
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Authors

ABOUT THE EDITORS vii

CONTRIBUTORS ix

INTRODUCTION 1

1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3
Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng

2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29
Guo-Qiang Lin and Xing-Wen Sun

3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77
Jianqiang Wang and Wenya Lu

4 RESOLUTION OF CHIRAL DRUGS 137
Qi-Dong You

5 FLUORINE-CONTAINING CHIRAL DRUGS 195
Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing

6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253
Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni

7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297
Deping Wang and Eric Hu

8 PHARMACOLOGY OF CHIRAL DRUGS 323
Yongge Liu and Xiao-Hui Gu

9 PHARMACOKINETICS OF CHIRAL DRUGS 347
Hanqing Dong, Xiaochuan Guo and Zengbiao Li

10 TOXICOLOGY OF CHIRAL DRUGS 381
Guang Yang and Hai-Zhi Bu

11 REPRESENTATIVE CHIRAL DRUGS 401
Jiangqin Sun, Dingguo Liu, and Zhimin Wang

INDEX 449


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Chiral Drugs: Chemistry and Biological Action, An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties
Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and , Chiral Drugs: Chemistry and Biological Action

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Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and , Chiral Drugs: Chemistry and Biological Action

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