Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics Book

1 Overview of Mass Spectrometry Technologies for Examining Protein Structure: Current and Future Directions Shannon M. Swiatkowski Swiatkowski, Shannon M. Mark R. Chance Chance, Mark R. 1

2 Hydrogen Exchange Mass Spectrometry: Principles and Capabilities Sebastien Brier Brier, Sebastien John R. Engen Engen, John R. 11

3 Covalent Labeling Methods for Examining Protein Structure and Protein Interactions Keiji Takamoto Takamoto, Keiji Janna Kiselar Kiselar, Janna 45

4 Complementary Methods for Structure Determination: Hydroxyl-Radical-Mediated Footprinting and Deuterium Exchange Mass Spectrometry as Applied to Serpin Structure Xiaojing Zheng Zheng, Xiaojing Patrick L. Wintrode Wintrode, Patrick L. 69

5 Deuterium Exchange Approaches for Examining Protein Interactions: Case Studies of Complex Formation Elizabeth A. Komives Komives, Elizabeth A. 91

6 Hydrogen/Deuterium Exchange Studies of Viruses Sebyung Kang Kang, Sebyung Peter E. Prevelige, Jr. Prevelige, Peter E., Jr. 105

7 Use of Enhanced Peptide Amide Hydrogen/Deuterium Exchange-Mass Spectrometry (DXMS) in the Examination of Protein-Protein Interactions Yoshitomo Hamuro Hamuro, Yoshitomo Stephen J. Coales Coales, Stephen J. Lora L. Hamuro Hamuro, Lora L. Virgil L. Woods, Jr. Woods, Virgil L., Jr. 123

8 Cross-linking as a Tool to Examine Protein Complexes: Examples of Cross-linking Strategies and Computational Modeling Evgeniy V. Petrotchenko Petrotchenko, Evgeniy V. Christoph H. Borchers Borchers, Christoph H. 157

9 Complex Formation in the Actin Cytoskeleton: Cross-linking Tools to Define Actin Protein Structure and Interactions Sabrina Benchaar Benchaar, Sabrina Emil Reisler Reisler, Emil 169

10Computational Approaches to Examining Protein-Protein Interactions: Combining Experimental and Computational Data in the Era of Structural Genomics J. K. Amisha Kamal Kamal, J. K. Amisha 189

11 Studies of Intact Proteins and Protein Complexes: ESI MS Approaches Igor A. Kaltashov Kaltashov, Igor A. Rinat R. Abzalimov Abzalimov, Rinat R. Agya K. Frimpong Frimpong, Agya K. Stephen J. Eyles Eyles, Stephen J. 217

12 Two Approaches to Mass Spectrometric Protein Footprinting: PLIMSTEX and FPOP Michael L. Cross Cross, Michael L. Mei M. Zhu Mei, M. Zhu David M. Hambly Hambly, David M. 243

Index 271