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Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173 Book

Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173
Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173, Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, <i>Liquid Chromatography Time-of-Flight M, Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173 has a rating of 3 stars
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Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173, Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight M, Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173
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  • Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173
  • Written by author Imma Ferrer
  • Published by Wiley, John & Sons, Incorporated, April 2009
  • Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight M
  • The most advanced techniques for analyzing unknown and emerging contaminantsn recent years, we have witnessed an increase in mass accuracy from greater than 5 ppm to less than 1 ppm. At the same time, resolving power for benchtop time-of-flight mass in
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Authors

Preface vii

Contributors xi

Part I Principles and Theoretical Aspects of Accurate Mass

Chapter 1 Accurate Mass Measurements with Orthogonal Axis Time-of-Flight Mass Spectrometry John C. Fjeldsted 3

Chapter 2 The Mass Defect, Isotope Clusters, and Accurate Mass for Elemental Determination E. Michael Thurman Imma Ferrer 17

Part II Tools for Unknown Identification Using Accurate Mass

Chapter 3 Ion Compositions Determined with Increasing Simplicity Andrew H. Grange G. Wayne Sovocool 35

Chapter 4 Existence and Use of Accurate Mass Databases and Elemental Composition Tools for Target and Non-Target Analyses Imma Ferrer E. Michael Thurman 57

Chapter 5 Use of UPLC-(Q)TOF MS for Rapid Screening of Organic Micropollutants in Water Felix Hernandez Juan V. Sancho Maria Ibanez 71

Chapter 6 The Use of Accurate Mass, Isotope Ratios, and MS/MS for the Analysis of PPCPs in Water Michael C. Zumwalt 89

Part III Applications of LC/TOF-MS for the Identification of Small Molecules

Chapter 7 Applications of LC/TOF-MS in the Environmental Field: When did it Start and Where is it Going? Imma Ferrer E. Michael Thurman 105

Chapter 8 Liquid Chromatography and Ambient Ionization Time-of-Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals Facundo M. Fernandez Christina Y. Hampton Leonard Nyadong Arti Navare Mark Kwasnik 113

Chapter 9 Quantitative Analysis of Veterinary Drug Residues By Sub 2-μm Particulate High-Performance Liquid Chromatography Columns and Time-of-Flight Mass Spectrometry (UPLC-TOF) Anton Kaufmann 133

Chapter 10 Industrial Applications of Liquid Chromatography Time-of-Flight Mass Spectrometry Jeffrey R. Gilbert Jesse L. Balcer ScottA. Young Dan A. Markham Dennis O. Duebelbeis Paul Lewer 151

Chapter 11 Comprehensive Toxicological and Forensic Drug Screening by LC/TOF-MS Ilkka Ojanpera Anna Pelander Suvi Ojanpera 173

Chapter 12 Application of UPLC/TOF-MS for Residue Analysis of Veterinary Drugs and Growth-Promoting Agents in Products of Animal Origin Alida (Linda) A.M. Stolker 197

Chapter 13 Accurate Mass Measurements with a Reflectron Time-of-Flight Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for the Identification of Unknown Compounds Below Masses of 500 DA O. David Sparkman Patrick R. Jones Matthew Curtis 229

Chapter 14 Comparison of LC/TOF-MS and LC/MS-MS for the Analysis of 100 Pesticides in Food: Finding the "Crossover Point" E. Michael Thurman Imma Ferrer Jerry A. Zweigenbaum Paul A. Zavitsanos 247

Index 259


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Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173, Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, <i>Liquid Chromatography Time-of-Flight M, Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173

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Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173, Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, <i>Liquid Chromatography Time-of-Flight M, Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173

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Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173, Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, <i>Liquid Chromatography Time-of-Flight M, Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173

Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Vol. 173

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