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Symposium on Heart failure: molecules, mechanisms and therapeutic targets, held at the Novartis Foundation, 26-28 April 2005
Editors: Gregory Bock (Organizer) and Jamie Goode
This symposium is based on a proposal made by Eric N. Olson
Introduction 1
Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation 3
Discussion 13
A novel mechanism of mechanical stress-induced hypertrophy 20
Discussion 31
Controlling cardiomyocyte survival 41
Discussion 51
Mechanisms of angiotensin Il-dependent progression to heart failure 58
Discussion 68
Alterations in myocardial gene expression as a basis for cardiomyopathies and heart failure 73
Discussion 83
Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy 90
Discussion 111
Role of Akt in cardiac growth and metabolism 118
Discussion 126
Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors 132
Discussion 147
General discussion I 152
Phospholamban as a therapeutic modality in heart failure 156
Discussion 172
Sarcomere protein gene mutations and inherited heart disease: a [Beta]-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure 176
Discussion 189
The cardiomyocyte cell cycle 196
Discussion 208
Restoration of cardiac function with progenitor cells 214
Discussion 223
Signalling pathways in cardiac regeneration 228
Discussion 239
Beyond small molecule drugs for heart failure: prospects for gene therapy 244
Discussion 256
Dual roles of telomerase in cardiac protection and repair 260
Discussion 267
Final general discussion 272
Closing remarks: historical perspective 277
Index of contributors 280
Subject index 282
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Josephine Esposito
reviewed Heart Failure: Molecules, Mechanisms and Therapeutic Targets on May 12, 2012 Heart Failure
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Add Heart Failure: Molecules, Mechanisms and Therapeutic Targets, Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dr, Heart Failure: Molecules, Mechanisms and Therapeutic Targets to the inventory that you are selling on WonderClubX
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Add Heart Failure: Molecules, Mechanisms and Therapeutic Targets, Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dr, Heart Failure: Molecules, Mechanisms and Therapeutic Targets to your collection on WonderClub |