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| Preface | ||
| A Note About S-PLUS Versions | ||
| Typographic Conventions | ||
| Companion Web Site for This Book | ||
| Information on S-PLUS | ||
| Acknowledgments | ||
| List of Contributors | ||
| Pt. 1 | Introduction | 1 |
| 1 | Statistics and the Drug Development Process | 3 |
| Pt. 2 | Basic Research and Preclinical Studies | 15 |
| 2 | One-Factor Comparative Studies | 17 |
| Pt. 3 | Pre-Clinical Safety Assessment | 41 |
| 3 | Analysis of Animal Carcinogenicity Data | 43 |
| 4 | Analysis of Toxicokinetic and Pharmacokinetic Data from Animal Studies | 75 |
| Pt. 4 | Phase I Studies | 107 |
| 5 | Analysis of Pharmacokinetic Data | 109 |
| 6 | Graphical Presentation of Single Patient Results | 135 |
| 7 | Graphical Insight and Data Analysis for the 2,2,2 Crossover Design | 153 |
| 8 | Design and Analysis of Phase I Trials in Clinical Oncology | 189 |
| 9 | Patient Compliance and its Impact on Steady State Pharmacokinetics | 217 |
| 10 | Analysis of Analgesic Trials | 237 |
| Pt. 5 | Phase II and Phase III Clinical Trials | 267 |
| 11 | Power and Sample Size Calculations | 269 |
| 12 | Comparing Two Treatments in a Large Phase III Clinical Trial | 299 |
| 13 | Analysis of Variance: A Comparison Between SAS and S-PLUS | 321 |
| 14 | Permutation Tests for Phase III Clinical Trials | 349 |
| 15 | Sample Size Reestimation | 375 |
| 16 | Meta-Analysis of Clinical Trials | 397 |
| Pt. 6 | Phase IV Studies | 425 |
| 17 | Analysis of Health Economic Data | 427 |
| Pt. 7 | Manufacturing and Production | 455 |
| 18 | Evaluation of the Decimal Reduction Time of a Sterilization Process in Pharmaceutical Production | 457 |
| 19 | Acceptance Sampling Plans by Attributes | 475 |
| Index | 503 |
| Price | Condition | Delivery | Seller | Action |
| $109.00 | Digital |
| WonderClub |
William Wood
reviewed Applied Statistics in the Pharmaceutical Industry: With Case Studies Using S-PLUS on November 12, 2013
Applied Statistics in the Pharmaceutical Industry
Aus Seite 210:
Man hatte Gedanken auf der einen Seite und Gehirnstrukturen auf der anderen, aber man hatte nicht die leiseste Ahnung wie beides zusammenzubringen sei..
All die ist heute anders.. psychologische Sachverhalte - bis hin zu rein subjektiven Gedanken, Gefühlen und Empfindungen [können wir:] am Computer .. simulieren...
Psychologische Theorien der Vergangenheit zeichnete sich sehr oft durch eine große Vagheit aus, so daß man sie mit nahezu allen Beobachtungen in Einklang bringen konnte. Damit waren die Theorien einerseits gegen ihre Widerlegungn immun, anderseits jedoch praktisch nutzlos..
Die Kritik des unmittelbar bevorstehenden Absatzes gilt ebensogut auf anderen Bereichen; man denkt nur an Epistomotologie oder pedagoische Theorien. Nun erhebt die in diesem Buch vorgetragenen Ideen die Psychologie aus seiner willkürlich ausgeprägten Zustand in die Reihe der objektiv meßbaren Wissenschaften. Dies erfolgt nach dem Schema der Physik, wobei weitgefächerte makroskopische Merkmale auf der Basis von einer kleinen Zahl mikroskopischen Eigenschaften erklärt werden.
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