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The Evaluation of Surrogate Endpoints Book

The Evaluation of Surrogate Endpoints
The Evaluation of Surrogate Endpoints, , The Evaluation of Surrogate Endpoints has a rating of 3 stars
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  • The Evaluation of Surrogate Endpoints
  • Written by author Tomasz Burzykowski
  • Published by Springer-Verlag New York, LLC, February 2005
  • Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other
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Book Categories

Authors

1Introduction1
2Setting the scene7
3Regulatory aspects in using surrogate markers in clinical trials13
4Notation and motivating studies53
5The history of surrogate endpoint validation67
6Validation using single-trial data : mixed binary and continuous outcomes83
7A meta-analytic validation framework for continuous outcomes95
8The choice of units121
9Extensions of the meta-analytic approach to surrogate endpoints143
10Meta-analytic validation with binary outcomes153
11Validation in the case of two failure-time endpoints163
12An ordinal surrogate for a survival true endpoint195
13A combination of longitudinal and survival endpoints219
14Repeated measures and surrogate endpoint validation231
15Bayesian evaluation of surrogate endpoints253
16Surrogate marker validation in mental health271
17The evaluation of surrogate endpoints in practice : experience in HIV295
18An alternative measure for meta-analytic surrogate endpoint validation323
19Discussion : surrogate endpoint definition and evaluation341
20The promise and peril of surrogate endpoints in cancer research349


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