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1 | Introduction | 1 |
2 | Setting the scene | 7 |
3 | Regulatory aspects in using surrogate markers in clinical trials | 13 |
4 | Notation and motivating studies | 53 |
5 | The history of surrogate endpoint validation | 67 |
6 | Validation using single-trial data : mixed binary and continuous outcomes | 83 |
7 | A meta-analytic validation framework for continuous outcomes | 95 |
8 | The choice of units | 121 |
9 | Extensions of the meta-analytic approach to surrogate endpoints | 143 |
10 | Meta-analytic validation with binary outcomes | 153 |
11 | Validation in the case of two failure-time endpoints | 163 |
12 | An ordinal surrogate for a survival true endpoint | 195 |
13 | A combination of longitudinal and survival endpoints | 219 |
14 | Repeated measures and surrogate endpoint validation | 231 |
15 | Bayesian evaluation of surrogate endpoints | 253 |
16 | Surrogate marker validation in mental health | 271 |
17 | The evaluation of surrogate endpoints in practice : experience in HIV | 295 |
18 | An alternative measure for meta-analytic surrogate endpoint validation | 323 |
19 | Discussion : surrogate endpoint definition and evaluation | 341 |
20 | The promise and peril of surrogate endpoints in cancer research | 349 |
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