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Telomerases, Telomeres and Cancer Book

Telomerases, Telomeres and Cancer
Telomerases, Telomeres and Cancer, , Telomerases, Telomeres and Cancer has a rating of 3 stars
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  • Telomerases, Telomeres and Cancer
  • Written by author Guido Krupp
  • Published by Springer-Verlag New York, LLC, October 2001
  • Medical researchers and biochemists contribute papers exploring relationships between telomeres, telomerase, and the growth of cancer cells. The 28 articles from international contributors are edited by Krupp (Nobistor, Hamburg, Germany) and Parwaresch (C
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Sect. ITelomerases, Telomeres and Cancer1
1The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers3
2The Role of Telomerase De-Regulation in Keratinocyte Immortality and the Progression of Human Head and Neck Cancer13
3Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications24
4Telomerase Activity in Mesenchymal Tumors41
5Telomerase Activity in Neuroblastomas: A New Molecular Market for Treatment Stratification and Prognostic Grouping47
6Telomerase and Radiosensitivity of Human Tumors60
7Amplification of hTERT, the Telomerase Reverse Transcriptase Gene in Human Cancers79
8Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment84
9PNA and Oligonucleotide Inhibitors of Human Telomerase100
10Potential of the Telomerase Catalytic Subunit as a Universal Tumor-Associated Antigen for Cancer Immunotherapy114
Sect. IIStructure and Function of Telomerases and Telomeres121
11The Makings of Telomerases123
12Regulation of Telomerase Activity134
13Telomeres and Mechanisms of DNA Double Strand Break Repair160
14Roles for hTERT and Telomerase in Cell Differentiation and Apoptosis168
15Human, Mouse and Yeast Telomerase182
16The Biology of Telomeres in Hypotrichous Ciliates205
17DNA Primer Extension by Telomerase223
18Yeast Telomerases: Structure, Mechanisms and Regulation239
19RAP1 Binding and Length Regulation of Yeast Telomeres259
20Linear Plasmids in Yeasts and Filamentous Fungi282
21New Telomere Formation During the Process of Chromatin Diminution in the Parasitic Nematodes Ascaris suum and Parascaris univalens291
22Telomerase Activity in Sponges (Porifera), the Closest Related Taxa of the Hypothetical Ancestral Animal the Urmetazoa300
23Structure and Maintenance of Chromosome Ends in Plants314
Sect. IIIMaintaining Telomeres without Telomerase333
24Telomeres without Telomerase in Saccharomyces cerevisiae334
25Recombinational Telomere Elongation in the Yeast Kluyveromyces lactis347
26Telomere Maintenance in Human Cell Lines and Tumors without Telomerase359
Sect. IVNon-Classical Telomere Structures375
27Telomeres in Drosophila and Other Insects376
28Mitochondrial Telomeres: Alternative Solutions to the End-Replication Problem396
Index418


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