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Sect. I | Telomerases, Telomeres and Cancer | 1 |
1 | The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers | 3 |
2 | The Role of Telomerase De-Regulation in Keratinocyte Immortality and the Progression of Human Head and Neck Cancer | 13 |
3 | Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications | 24 |
4 | Telomerase Activity in Mesenchymal Tumors | 41 |
5 | Telomerase Activity in Neuroblastomas: A New Molecular Market for Treatment Stratification and Prognostic Grouping | 47 |
6 | Telomerase and Radiosensitivity of Human Tumors | 60 |
7 | Amplification of hTERT, the Telomerase Reverse Transcriptase Gene in Human Cancers | 79 |
8 | Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment | 84 |
9 | PNA and Oligonucleotide Inhibitors of Human Telomerase | 100 |
10 | Potential of the Telomerase Catalytic Subunit as a Universal Tumor-Associated Antigen for Cancer Immunotherapy | 114 |
Sect. II | Structure and Function of Telomerases and Telomeres | 121 |
11 | The Makings of Telomerases | 123 |
12 | Regulation of Telomerase Activity | 134 |
13 | Telomeres and Mechanisms of DNA Double Strand Break Repair | 160 |
14 | Roles for hTERT and Telomerase in Cell Differentiation and Apoptosis | 168 |
15 | Human, Mouse and Yeast Telomerase | 182 |
16 | The Biology of Telomeres in Hypotrichous Ciliates | 205 |
17 | DNA Primer Extension by Telomerase | 223 |
18 | Yeast Telomerases: Structure, Mechanisms and Regulation | 239 |
19 | RAP1 Binding and Length Regulation of Yeast Telomeres | 259 |
20 | Linear Plasmids in Yeasts and Filamentous Fungi | 282 |
21 | New Telomere Formation During the Process of Chromatin Diminution in the Parasitic Nematodes Ascaris suum and Parascaris univalens | 291 |
22 | Telomerase Activity in Sponges (Porifera), the Closest Related Taxa of the Hypothetical Ancestral Animal the Urmetazoa | 300 |
23 | Structure and Maintenance of Chromosome Ends in Plants | 314 |
Sect. III | Maintaining Telomeres without Telomerase | 333 |
24 | Telomeres without Telomerase in Saccharomyces cerevisiae | 334 |
25 | Recombinational Telomere Elongation in the Yeast Kluyveromyces lactis | 347 |
26 | Telomere Maintenance in Human Cell Lines and Tumors without Telomerase | 359 |
Sect. IV | Non-Classical Telomere Structures | 375 |
27 | Telomeres in Drosophila and Other Insects | 376 |
28 | Mitochondrial Telomeres: Alternative Solutions to the End-Replication Problem | 396 |
Index | 418 |
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