Cancer Gene Therapy Past Achievements And Future Challenges Book

I	The Clinical Problem
1	Management Problems in Oncology	3
II	Vectors
2	Adenoviral Vectors	13
3	Retrovirus Vectors	23
4	Targetable Gene Delivery Vectors	37
5	Human [alpha]-fetoprotein Transcriptional Regulatory Sequences: Application to Gene Therapy	47
6	Tumor-Targeted Salmonella: Highly Selective Delivery Vectors	57
7	Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells	65
8	Polyoma and Papilloma Virus Vectors for Cancer Gene Therapy	73
9	Cochleates: Lipid-Based Vehicles for Gene Delivery - Concept, Achievements and Future Development	83
10	The Use of Skeletal Muscle to Express Genes for the Treatment of Cancer	95
III	Cell Cycle Control
11	Adhesion Molecules in Cancer Biology	115
12	Cell Cycle Control	127
IV	Apoptosis
13	Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death	143
14	Apoptin	153
15	Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors	163
16	Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer	171
V	Tumour Suppressor Genes
17	Pre-clinical Studies with Tumor Suppressor Genes	183
18	Gene Therapy for Liver Tumors	193
19	Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer	207
VI	Other Systems
20	Eliciting Hyperacute Rejection as a Tumor Killing Strategy: Herpes Amplicon Vector Transfer of the [alpha](1,3)Galactosyltransferase Gene	217
21	Innate Immune Therapy for Cancer: Screen for Molecules molecules of Activating the Innate Immune System	229
22	Mda-7: A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy	239
VII	Antisense and Ribozymes
23	Antisense IGF and Antisense IGF-IR Therapy of Malignancy	265
24	Sensitization of Tumors to Chemotherapy Through Gene Therapy	273
25	Design and Testing of Ribozymes for Cancer Gene Therapy	293
26	Ribozymes: Their Design and Use in Cancer	303
27	The Approach of Triple Helix Formation in Control of Gene Expression and the Treatment of Tumors Expressing IGF-1	319
VIII	Immuno-Modulation
28	Dendritic Cell-based Immunization for Cancer Therapy	335
29	Hybrid Cell Vaccination for Cancer Immunotherapy	347
30	Modulation of the Immune Response Through 4-1BB	355
31	Heat Shock Proteins in Cancer Therapy	363
32	Bi-Specific Antibodies in Cancer Therapy	369
33	B7.1 and Cytokines: Synergy in Cancer Gene Therapy	381
34	Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma	391
IX	Suicidal Genes
35	Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT)	403
36	Suicide Gene Therapy	411
37	Adenoviruses as Gene Delivery Vectors	423
X	Angiogenesis Control
38	Evaluation of an Inhibitor of DNA Methylation, 5-aza-2-deoxycytidine, for the Treatment of Lung Cancer and the Future Role of Gene Therapy	433
39	Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy	447
40	Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy	457
XI	Matrix Metallo Proteinase
41	Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression for Cancer Gene Therapy	469
	Contributors	485
	Index	495