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Book Categories |
Historical Aspects | ||
Heparin - An Introduction | 1 | |
Structural Properties of Heparin and Heparan Sulphate | ||
Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans | 21 | |
Structural Analysis of Periodate-Oxidized Heparin | 31 | |
New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins | 37 | |
Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis | 49 | |
Heparin and Heparan Sulphate Proteoglycans - Cellular Aspects | ||
Regulation of the Gene that Encodes the Peptide Core of Heparin Proteoglycan and Other Proteoglycans that are Stored in the Secretory Granules of Hematopoietic Cells | 59 | |
Structural and Functional Diversity of the Heparan Sulphate Proteoglycans | 69 | |
Syndecan-ACell Surface Proteoglycan that Selectively Binds Extracellular Effector Molecules | 79 | |
Heparan Sulphate Proteoglycans and Signalling in Cell Adhesion | 87 | |
Heparin and Heparan Sulphate Proteoglycans - Interactions and Metabolism | ||
Animal Cell Mutants Defective in Heparan Sulphate Polymerization | 97 | |
Two Enzymes in One: N-Deacetyation and N-Sulpfation in Heparin Biosynthesis are Catalyzed by the Same Protein | 107 | |
Metabolism of Plasma Membrane-Associated Heparan Sulphate Proteoglycans | 113 | |
Lysosomal Degradation of Heparin and Heparan Sulphate | 121 | |
Heparin Binding Properties of the Carboxyl Terminal Domain of [A [superscript]103, 106, 108] Antristasin 93-119 | 135 | |
Heparin Protein Interactions | 141 | |
Anticoagulant Proteins | ||
Role of Protein Conformational Changes, Surface Approximation, and Protein Cofactors in Heparin-Accelerated Antithrombin-Proeinase Reactions | 155 | |
The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulphate Hexasaccharide | 167 | |
Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety | 177 | |
The Interaction Between LACI and Heparin | 189 | |
Tissue Pathway Inhibitor and Heparin | 199 | |
Antithrombotic Mechanisms | ||
LMW Heparin: Relationship Between Antithrombotic and Anticoagulant Effects | 205 | |
The Mode of Action of Heparins In Vitro and In Vivo | 221 | |
Prophylactically Effective Doses of Enoxaparin and Heparin Inhibit Prothrombin Activation | 231 | |
Clinical Use | ||
Pharmacokinetics of Heparin and of Dematan Sulphate: Clinical Implications | 237 | |
Heparin in the Prevention and Treatment of Arterial Thromboembolism | 249 | |
Glycosaminoglycans in the Prophylaxis Against Venous Thromboembolism | 259 | |
Treatment of Deep Vein Thrombosis (DVT) with Low Molecular Weight Heparin (LMWH) | 275 | |
Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin | 283 | |
New Perspectives (E. Jorpes Symposium) | ||
Regulation of Protease Nexin-1 Activity by Heparin and Heparan Sulphate | 297 | |
New Approaches for Defining Sequence Specific Synthesis of Heparan Sulphate Chains | 307 | |
Modulation of Neovascularization and Metastasis Species of Heparin | 317 | |
Anti-inflammatory Effects of Heparin and its Derivatives: Inhibition of Complement and of Lymphocyte Migration | 329 | |
Heparan Sulphate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus | 341 | |
Control of Angiogenesis by Heparin and Other Sulphated Polysaccharides | 355 | |
Index | 365 |
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