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Heparin And Related Polysaccharides Book

Heparin And Related Polysaccharides
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  • Heparin And Related Polysaccharides
  • Written by author D. A. Lane
  • Published by Springer-Verlag New York, LLC, September 1992
Buy Digital  USD$306.24

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Historical Aspects
Heparin - An Introduction1
Structural Properties of Heparin and Heparan Sulphate
Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans21
Structural Analysis of Periodate-Oxidized Heparin31
New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins37
Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis49
Heparin and Heparan Sulphate Proteoglycans - Cellular Aspects
Regulation of the Gene that Encodes the Peptide Core of Heparin Proteoglycan and Other Proteoglycans that are Stored in the Secretory Granules of Hematopoietic Cells59
Structural and Functional Diversity of the Heparan Sulphate Proteoglycans69
Syndecan-ACell Surface Proteoglycan that Selectively Binds Extracellular Effector Molecules79
Heparan Sulphate Proteoglycans and Signalling in Cell Adhesion87
Heparin and Heparan Sulphate Proteoglycans - Interactions and Metabolism
Animal Cell Mutants Defective in Heparan Sulphate Polymerization97
Two Enzymes in One: N-Deacetyation and N-Sulpfation in Heparin Biosynthesis are Catalyzed by the Same Protein107
Metabolism of Plasma Membrane-Associated Heparan Sulphate Proteoglycans113
Lysosomal Degradation of Heparin and Heparan Sulphate121
Heparin Binding Properties of the Carboxyl Terminal Domain of [A [superscript]103, 106, 108] Antristasin 93-119135
Heparin Protein Interactions141
Anticoagulant Proteins
Role of Protein Conformational Changes, Surface Approximation, and Protein Cofactors in Heparin-Accelerated Antithrombin-Proeinase Reactions155
The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulphate Hexasaccharide167
Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety177
The Interaction Between LACI and Heparin189
Tissue Pathway Inhibitor and Heparin199
Antithrombotic Mechanisms
LMW Heparin: Relationship Between Antithrombotic and Anticoagulant Effects205
The Mode of Action of Heparins In Vitro and In Vivo221
Prophylactically Effective Doses of Enoxaparin and Heparin Inhibit Prothrombin Activation231
Clinical Use
Pharmacokinetics of Heparin and of Dematan Sulphate: Clinical Implications237
Heparin in the Prevention and Treatment of Arterial Thromboembolism249
Glycosaminoglycans in the Prophylaxis Against Venous Thromboembolism259
Treatment of Deep Vein Thrombosis (DVT) with Low Molecular Weight Heparin (LMWH)275
Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin283
New Perspectives (E. Jorpes Symposium)
Regulation of Protease Nexin-1 Activity by Heparin and Heparan Sulphate297
New Approaches for Defining Sequence Specific Synthesis of Heparan Sulphate Chains307
Modulation of Neovascularization and Metastasis Species of Heparin317
Anti-inflammatory Effects of Heparin and its Derivatives: Inhibition of Complement and of Lymphocyte Migration329
Heparan Sulphate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus341
Control of Angiogenesis by Heparin and Other Sulphated Polysaccharides355
Index365


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