Neurobiology of Mental Illness Book

Table of Contents

Contributors

Preface

SECTION 1: Introduction to Basic Neuroscience Eric J. Nestler

1. Overview of Brain Development John L. R. Rubenstein

2. Neurochemical Systems in the Central Nervous System Ariel Y. Deutch and Robert H. Roth

3. Principles of Electrophysiology Evelyn K. Lambe

4. Principles of Signal Transduction Jean-Antoine Girault and Paul Greengard

5. Synaptic and Neural Plasticity Saïd Kourrich and Antonello Bonci

6. Principles of Molecular Biology Steven E. Hyman and Eric J. Nestler

7. Epigenetics of Psychiatric Diseases Bryan E. McGill and Huda Y. Zoghbi

SECTION 2: Emerging Technologies Karl Deisseroth

8. Transgenic Tools and Animal Models of Mental Illness Lisa M. Monteggia, William Carlezon, Jr. and Ralph J. DiLeone

9. Application of Stem Cells to Understanding Psychiatric Disorders Kimberly M. Christian, Hongjun Song and Guo-li Ming

10. Optogenetic Technologies for Psychiatric Disease Research: Current Status and Challenges Lief E. Fenno and Karl Deisseroth

11. Applications of Focused Ultrasound Elisa E. Konofagou

12. Genetic Methodologies and Applications Shaun M. Purcell

13. The Brain and Its Epigenome Amanda C. Mitchell, Yan Jiang, Cyril J. Peter, Ki A. Goosens and Schahram Akbarian

14. Network Methods for Elucidating the Complexity of Common Human Diseases Eric E. Schadt

15. Brain Imaging Methodologies Hanzhang Lu, Yihong Yang and Peiying Liu

16. Image-Guided Brain Stimulation Mark S. George, John J. Taylor and Jaimie Henderson

SECTION 3: Psychotic Disorders Pamela Sklar

17. Diagnosis of the Psychoses Lianne Morris Smith, Julie W. Messinger and Dolores Malaspina

18. Genetics of Schizophrenia and Bipolar Disorder Pamela Sklar

19. Genomic Syndromes in Schizophrenia: Overlapping Phenotypes George Kirov, Michael O'Donovan and Michael J. Owen

20. Neuroimaging of Psychotic Disorders Stephan Heckers, Neil Woodward and Dost Ongur

21. Cognitive and Motivational Neuroscience of Psychotic Disorders Alan Anticevic, Erin C. Dowd and Deanna M. Barch

22. Mouse Models of Schizophrenia and Bipolar Disorder Mikhail V. Pletnikov and Christopher A. Ross

23. Cortical GABA Neurons in Schizophrenia Allison A. Curley and David A. Lewis

24. Synaptic Disease in Psychiatry Seth G. N. Grant

25. Neurodevelopment and Schizophrenia Ester J. Kwon, Takahiro Soda and Li-Huei Tsai

26. Psychosis Proneness Raquel E. Gur

27. Neurochemistry and Pharmacotherapy Carol A. Tamminga and Elena I. Ivleva

28. Neurobiology of Bipolar Disorder Kate Burdick, Stephen Haggarty and Roy Perlis

SECTION 4: Mood Disorders Helen S. Mayberg

29. The Diagnosis of Mood Disorders Jan Fawcett and Brant Hager

30. Genetics of Depression Douglas F. Levinson

31. Animal Models of Mood Disorders Georgia E. Hodes and Scott J. Russo

32. Molecular and Cellular Pathogenesis of Depression and Mechanisms for Treatment Response Ronald S. Duman

33. Pathogenesis of Depression: Clinical Studies Maura A. Furey, Daniel C. Mathews and Carlos A. Zarate Jr.

34. Neural Circuitry of Depression Joseph L. Price and Wayne C. Drevets

35. Neurobiology of Depression in Later Life: Anatomy of Melancholia K. Ranga Rama Krishnan

36. Gonadal Steroids and Mood Disorders David R. Rubinow, Peter J. Schmidt and Claire D. Craft

37. Depression and Medical Illness Tami D. Benton, Joshua Blume, Paul Crits-Christoph, Benoit Dube and Dwight L. Evans

38. Treatments for Depression Dan V. Iosifescu, James W. Murrough and Dennis S. Charney

SECTION 5: Anxiety Disorders Kerry J. Ressler

39. Diagnosis of Anxiety Disorders Meghan E. Keough, Murray B. Stein and Peter P. Roy-Byrne

40. Genetics of Anxiety Disorders Javier A. Perez, Takeshi Otowa, Roxann Roberson-Nay and John M. Hettema

41. The Neurobiology of Fear and Anxiety: Contributions of Animal Models to Current Understanding Christopher K. Cain, Gregory Sullivan and Joseph E. LeDoux

42. Differential roles of GABA Receptors in Anxiety Hanns Möhler

43. Prefrontal Cortex Regulation of Emotion and Anxiety Bronwyn M. Graham and Mohammed R. Milad

44. Developmental Components of Fear and Anxiety in Animal Models Siobhan S. Pattwell, Anne-Marie Mouly, Regina M. Sullivan and Francis S. Lee

45. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders Madeleine S. Goodkind, Anett Gyurak and Amit Etkin

46. Novel Treatment Approaches for Anxiety Disorders Anita Van Zwieten, Gail A. Alvares & Adam J. Guastella

47. Pharmacotherapy of Anxiety Disorders Dan V. Iosifescu, James W. Murrough and Dennis S. Charney

48. Neurobiology and Treatment of OCD Susanne E. Ahmari and H. Blair Simpson

49. Neurobiology and Treatment of PTSD Karen E. Murray, Orion P. Keifer, Jr., Kerry J. Ressler, Seth Davin Norrholm and Tanja Jovanovic

SECTION 6: Substance Use Disorders Antonello Bonci and Nora Volkow

50. Animal Models of Addiction Christopher J. Evans, Rafael Maldonado López and Yvette F. Taché

51. Cellular and Molecular Mechanisms of Addiction Kathryn J. Reissner and Peter W. Kalivas

52. The Genetic Basis of Addictive Disorders David Goldman

53. Brain Development and the Risk for Substance Abuse Kristina Caudle and BJ Casey

54. Molecular Imaging in Addictive Disorders Chelsea L. Robertson, Steven M. Berman and Edythe D. London

55. Brain, Reward, and Drug Addiction Vani Pariyadath, Martin P. Paulus and Elliot A. Stein

56. Magnetic Resonance Spectroscopy Studies in Substance Abusers Linda Chang, Christine C. Cloak and John L. Holt

57. Pharmacotherapy of Substance Use Disorders Jane B. Acri and Philip Skolnick

58. Epidemiology of Substance Use Disorders Denise B. Kandel, Mei-Chen Hu and Pamela C. Griesler

SECTION 7: Dementia David M. Holtzman

59. Clinical and Neuropsychological Features of Alzheimer's Disease Jason Hassenstab, Jeffrey Burns and John C. Morris

60. The Genetics of Alzheimer's Disease Rudolph E. Tanzi

61. Experimental Animal Models of Alzheimer's Disease Dave Morgan

62. Structural, Functional and Molecular Neuroimaging Biomarkers for Alzheimer's Disease James B. Brewer, Jorge Sepulcre and Keith A. Johnson

63. Fluid Biomarkers for Alzheimer's Disease Anne M. Fagan

64. Current Therapies for Alzheimer's Disease Mary Sano and Judith A. Neugroschl

65. Disease-Modifying Therapies for Alzheimer's Disease Joshua D. Grill and Jeffrey Cummings

66. Lewy Body Dementias Stella Karantzoulis and James E. Galvin

67. Clinical Features and Pathogenesis of FTD Georges Naasan and Bruce Miller

68. Pathogenesis, Diagnosis and Treatment of Vascular and Mixed Dementias Helena Chang Chui

69. Clinical Features and Pathogenesis of Prion Disease Joel Watts and Michael D. Geschwind

SECTION 8: Psychiatric Disorders of Childhood Onset Joseph D. Buxbaum

70. Epidemiology of Neuropsychiatric and Developmental Disorders of Childhood Elise Robinson, Benjamin Neale and Mark J. Daly

71. Rare Variants of Substantial Effect in Psychiatric Disorders of Childhood Onset Heather C. Mefford

72. Epigenetics in Early Life Programming Tracy L. Bale

73. Animal Models in Psychiatric Disorders of Childhood Onset Richard Paylor, Alexia M. Thomas, Surabi Veeraragavan and Shannon M. Hamilton

74. Neuropathology and Synaptic Alterations in Neurodevelopmental Disorders Mara Dierssen and Salvador Martínez

75. Functional Connectivity: Application to Developmental Disorders Luke Bloy, Ragini Verma and Timothy P.L. Roberts

76. Intellectual Disability Syndromes Charles E. Schwartz, Fiorella Gurrieri and Giovanni Neri

77. Autism Spectrum Disorders Alexander Kolevzon, A. Ting Wang, David Grodberg and Joseph D. Buxbaum

78. Neurobiology of Attention Deficit Hyperactivity Disorder Stephen V. Faraone and Joseph Biederman

79. Tourette Syndrome and Tic Disorders Kyle Williams, Michael H. Bloch, Matthew W. State and Christopher Pittenger

80. Novel Therapeutics in Childhood Onset Psychiatric Disorders Dorothy E. Grice, Alexander Kolevzon, Walter E. Kaufmann and Joseph D. Buxbaum

SECTION 9: Special Topic Areas Dennis S. Charney

81. DSM-5 Overview and Goals David J. Kupfer and Susan K. Schultz

82. The Infirmities of Psychiatric Diagnosis Steven E. Hyman

83. Toward Precision Medicine in Psychiatry: The NIMH Research Domain Criteria Project Bruce N. Cuthbert and Thomas R. Insel

84. Neurobiology of Personality Disorders: The Shift in DSM-5
M. Mercedes Perez-Rodriguez, Antonia S. New and Larry J. Siever

85. The Neurobiology of Aggression R. James R. Blair

86. Neurobiology of Social Attachment Adam S. Smith, Kelly Lei and Zuoxin Wang

87. The Neurobiology of Sleep Giulio Tononi and Chiara Cirelli

88. The Neurobiology of Resilience Adriana Feder, Margaret Haglund, Gang Wu, Steven M. Southwick and Dennis S. Charney

89. Neurobiology of Eating Disorders Thomas B. Hildebrandt

Index