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Preface | ||
Ch. 1 | Legal Standards for the Admissibility of Novel Scientific Evidence | 1 |
Factors Affecting Reliance by the Courts on Scientific Evidence | 2 | |
The Motion in Limine | 3 | |
Standards for Admissibility | 5 | |
Ch. 2 | A Guide to the Analysis of Forensic Dust Specimens | 24 |
Occurrence, Collection, and Preservation of Dust Specimens | 26 | |
Initial Examination | 30 | |
Characterization and Identification Procedures | 32 | |
Ch. 3 | Forensic Applications of Infrared Spectroscopy | 71 |
Theory | 73 | |
Specificity and Limitations of Infrared Spectroscopy | 95 | |
Instrumentation | 103 | |
Sampling Techniques and Accessories | 116 | |
Applications | 130 | |
Future Directions | 159 | |
Ch. 4 | Infrared Microscopy and its Forensic Applications | 196 |
Optical Design | 198 | |
Spectral Measurement Methods and Sample Preparation | 214 | |
Applications | 221 | |
The Future | 245 | |
Ch. 5 | Forensic Pharmacology | 253 |
Basic Principles of Pharmacology | 254 | |
Other Drugs of Interest to the Forensic Scientist | 280 | |
Ch. 6 | Deoxyribonucleic Acid Structure and Function - A Review | 287 |
Chemical Composition | 289 | |
The Watson-Crick Model of DNA | 295 | |
Central Dogma | 301 | |
The Genetic Code | 302 | |
Methylation of Bases in DNA | 306 | |
Transaction and Translation | 307 | |
Introns | 311 | |
Chromosome Structure | 312 | |
DNA Synthesis in the Cell Cycle | 314 | |
Repetitious DNA | 323 | |
Restriction Enzymes | 327 | |
Mitochondrial DNA | 330 | |
Plasmids as Gene-Cloning Vectors | 332 | |
DNA Profiling (RFLP Analysis) | 333 | |
DNA Sequencing | 337 | |
Production of Transgenic Animals | 344 | |
Gene Therapy | 345 | |
Medical Benefits, Legal and Ethical Considerations | 346 | |
Ch. 7 | Forensic DNA Typing of Highly Polymorphic VNTR LOCI | 358 |
Fundamentals of DNA Structure | 359 | |
Genetic Markers Used for Forensic RFLP Typing | 361 | |
The RFLP Typing Procedure | 363 | |
Interpretation of RFLP Typing Results | 381 | |
Validity and Reliability of RFLP Typing and Data Interpretation | 389 | |
Appendix 7.1 Guidelines for a Quality Assurance Program for DNA Analysis | 398 | |
Ch. 8 | DNA Analysis in Biological Evidence: Applications of the Polymerase Chain Reaction | 416 |
The Polymerase Chain Reaction | 417 | |
Detection of Genetic Variation | 424 | |
Determination of Sex and Species Origin | 433 | |
Biological Evidence Analysis Using PCR | 435 | |
Interpretation of Results: Statistical Considerations | 442 | |
Index | 453 |
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