Multiple Sclerosis as a Neuronal Disease Book

1	The structure of myelinated axons in the CNS	1
2	Dialogues : communication between axons and myelinating glia	29
3	Molecular specializations at the glia-axon interface	45
4	Potassium channel organization of myelinated and demyelinated axons	57
5	The roles of potassium and calcium channels in physiology and pathophysiology of axons	69
6	The conduction properties of demyelinated and remyelinated axons	85
7	Altered distributions and functions of multiple sodium channel subtypes in multiple sclerosis and its models	101
8	Na[superscript +] channel reorganization in demyelinated axons	119
9	Ion currents and axonal oscillators : a possible biophysical basis for positive signs and symptoms in multiple sclerosis	131
10	Clinical pharmacology of abnormal potassium channel organization in demyelinated axons	145
11	Pathology of neurons in multiple sclerosis	153
12	Axonal degeneration in multiple sclerosis : the histopathological evidence	165
13	Natural history of multiple sclerosis : when do axons degenerate?	185
14	Brain atrophy as a measure of neurodegeneration and neuroprotection	201
15	MRI-clinical correlations in multiple sclerosis : implications for our understanding of neuronal changes	215
16	Electrophysiological correlates of relapse, remission, persistent sensorimotor deficit, and long-term recovery processes in multiple sclerosis	227
17	Inflammation and axon degeneration	241
18	Nitric oxide and axonal pathophysiology	255
19	Molecular mechanisms of calcium influx in axonal degeneration	275
20	Axonal damage and neuron death in multiple sclerosis and experimental autoimmune encephalomyelitis : the role of calpain	293
21	Mutations of myelination-associated genes that affect axonal integrity	305
22	Neuronal blocking factors in demyelinating diseases	317
23	Evidence for neuronal apoptosis in demyelinating CNS diseases	327
24	Mechanisms underlying Wallerian degeneration	341
25	AMAN : what it teaches us about mechanisms underlying axonal injury	355
26	Axonal degeneration as a predictor of outcome in neurological disorders	373
27	Remyelination as neuroprotection	389
28	Transplantation of peripheral-myelin-forming cells to repair demyelinated axons	421
29	Blocking the axonal injury cascade : neuroprotection in multiple sclerosis and its models	435
30	Functional brain reorganization and recovery after injury to white matter	451