Biomaterials Science: An Introduction to Materials in Medicine Book

	Biomaterials science : a multidisciplinary endeavor	1
	A history of biomaterials	10
Ch. 1	Properties of materials
1.1	Introduction	23
1.2	Bulk properties of materials	23
1.3	Finite element analysis	32
1.4	Surface properties and surface characterization of materials	40
1.5	Role of water in biomaterials	59
Ch. 2	Classes of materials used in medicine
2.1	Introduction	67
2.2	Polymers	67
2.3	Silicone biomaterials : history and chemistry	80
2.4	Medical fibers and biotextiles	86
2.5	Hydrogels	100
2.6	Applications of "smart polymers" as biomaterials	107
2.7	Bioresorbable and bioerodible materials	115
2.8	Natural materials	127
2.9	Metals	137
2.10	Ceramics, glasses, and glass-ceramics	153
2.11	Pyrolytic carbon for long-term medical implants	170
2.12	Composites	181
2.13	Nonfouling surfaces	197
2.14	Physicochemical surface modification of materials used in medicine	201
2.15	Textured and porous materials	218
2.16	Surface-immobilized biomolecules	225
Ch. 3	Some background concepts
3.1	Background concepts	237
3.2	The role of adsorbed proteins in tissue response to biomaterials	237
3.3	Cells and cell injury	246
3.4	Tissues, the extracellular matrix, and cell-biomaterial interactions	260
3.5	Mechanical forces on cells	282
Ch. 4	Host reactions to biomaterials and their evaluation
4.1	Introduction	293
4.2	Inflammation, wound healing, and the foreign-body response	296
4.3	Innate and adaptive immunity : the immune response to foreign materials	304
4.4	The complement system	318
4.5	Systemic toxicity and hypersensitivity	328
4.6	Blood coagulation and blood-materials interactions	332
4.7	Tumorigenesis and biomaterials	338
4.8	Biofilms, biomaterials, and device-related infections	345
Ch. 5	Biological testing of biomaterials
5.1	Introduction to testing biomaterials	355
5.2	In Vitro assessment of tissue compatibility	356
5.3	In Vivo assessment of tissue compatibility	360
5.4	Evaluation of blood-materials interactions	367
5.5	Large animal models in cardiac and vascular biomaterials research and testing	379
5.6	Microscopy for biomaterials science	396
Ch. 6	Degradation of materials in the biological environment
6.1	Introduction : degradation of materials in the biological environment	411
6.2	Chemical and biochemical degradation of polymers	411
6.3	Degradative effects of the biological environment on metals and ceramics	430
6.4	Pathological calcification of biomaterials	439
Ch. 7	Application of materials in medicine, biology, and artificial organs
7.1	Introduction	455
7.2	Nonthrombogenic treatments and strategies	456
7.3	Cardiovascular medical devices	470
7.4	Implantable cardiac assist devices	494
7.5	Artificial red blood cell substitutes	507
7.6	Extracorporeal artificial organs	514
7.7	Orthopedic applications	527
7.8	Dental implantation	556
7.9	Adhesives and sealants	573
7.10	Ophthalmological applications	584
7.11	Intraocular lens implants : a scientific perspective	592
7.12	Burn dressings and skin substitutes	603
7.13	Sutures	615
7.14	Drug delivery systems	629
7.15	Bioelectrodes	649
7.16	Cochlear prostheses	658
7.17	Biomedical sensors and biosensors	670
7.18	Diagnostics and biomaterials	685
7.19	Medical applications of silicones	698
Ch. 8	Tissue engineering
8.1	Introduction	709
8.2	Overview of tissue engineering	712
8.3	Immunoisolation	728
8.4	Synthetic bioresorbable polymer scaffolds	735
Ch. 9	Implants, devices, and biomaterials : issues unique to this field
9.1	Introduction	753
9.2	Sterilization of implants and devices	754
9.3	Implant and device failure	760
9.4	Correlation, surfaces and biomaterials science	765
9.5	Implant retrieval and evaluation	771
Ch. 10	New products and standards
10.1	Introduction	783
10.2	Voluntary consensus standards	783
10.3	Development and regulation of medical products using biomaterials	788
10.4	Ethical issues in the development of new biomaterials	793
10.5	Legal aspects of biomaterials	797
Ch. 11	Perspectives and possibilities in biomaterials science	805
App. A	Properties of biological fluids	813
App. B	Properties of soft materials	819
App. C	Chemical compositons of metals used for implants	823
App. D	The biomaterials literature	825