Principles of Gender-Specific Medicine Book

	Foreword
	Preface
Sect. 1	Gender and development
	Introduction	1
1	The role of gender in neonatology	3
2	Endocrinology and growth in children and adolescents	12
3	Gender-specific pulmonary disease	25
4	Gender-specific aspects of pediatric hematology and oncology	36
5	Gender differences in neurologic conditions of children	44
6	Gender and sports : past, present, and future	48
7	Gender differences in child and adolescent behavior	52
Sect. 2	Central nervous system
	Introduction	61
8	Gender differences in the functional organization of the brain	63
9	Do sex steroid hormones contribute to sexual differentiation of the human brain?	71
10	Hormonal and nonhormonal mechanisms of sexual differentiation of the brain	84
11	Neuroprotective effects of estrogen	96
12	Brain trauma, sex hormones, neuronal survival, and recovery of function	104
13	Gender differences in epilepsy	116
14	Sex hormones and headache	129
15	Gender differences in psychiatric disorders with a focus on estrogen	137
16	Gender differences in psychopharmacology	145
17	The question of psychosexual neutrality at birth	155
18	Treating psychologic disorders during pregnancy and lactation	167
Sect. 3	Cardiology
	Introduction	183
19	Gender and the heart : sex-specific differences in normal myocardial anatomy and physiology and in the experiences of some diseases of the cardiovascular system	185
20	Gender and its impact on risk factors for cardiovascular disease	193
21	Gender-specific aspects of the experience of coronary artery disease	215
22	Gender differences in the outcome of acute myocardial infarction	224
23	Dyslipidemia Management in women and men : exploring potential gender differences	234
24	Impact of gender on the response to cardioactive drugs	241
25	Hormone replacement therapy and cardioprotection	255
26	Gender differences in the role of stress and emotion in cardiovascular function and disease	263
27	Importance of and barriers to including women in clinical trials	275
Sect. 4	Pulmonology
	Introduction	283
28	Asthma : the need for different approaches by sex and gender	285
29	Sex, gender, and chronic obstructive pulmonary disease	299
30	Gender-specific considerations in interstitial lung disease	309
31	Gender-specific considerations in pulmonary hypertension	317
32	Venous thromboembolism: gender effects and gender-specific risk factors for women	332
33	The influence of gender on cough reflex sensitivity	347
34	Obstructive sleep apnea : why the gender bias?	355
35	Gender differences in the sepsis syndrome : clinical evidence and potential mechanisms	360
Sect. 5	Gastroenterology
	Introduction	375
36	Normal physiology of the gastrointestinal tract and gender differences	377
37	Gender differences in esophageal function	397
38	Sex-specific features of diseases of the stomach	406
39	Small intestine and colonic diseases	415
40	Gender considerations in inflammatory bowel disease	428
41	Gender-related differences in functional bowel disorders	438
42	Gallbladder and biliary diseases : more common in women, more severe in men	446
43	Effect of gender on pancreatic disease	454
44	Gender-specific issues in liver diseases	463
45	Gender difference in gastrointestinal endoscopy	477
Sect. 6	Reproductive biology
	Introduction	491
46	The birth of reproductive biology 1889 to 1940 : an historical perspective	493
47	Modern contraception in men and women	507
48	Ambiguous genitalia in the newborn	518
49	A practical approach to male infertility	538
50	Female infertility and assisted reproductive technology	550
51	Chronic pelvic pain in men and women : pathogenesis, diagnosis, and treatment	565
52	Male and female sexual dysfunction : epidemiology, pathophysiology, classifications, and treatment	573
53	Lower urogenital tract dysfunction in women and men	586
54	Colorectal disease in women and men	594
55	Aging and the lower urogenital system	602
56	The consequences of intersex conditions in adult life	615
Sect. 7	Oncology
	Introduction	627
57	Gender differences in hematologic malignancies	629
58	Effects of hormone deprivation in survivors of breast and prostate cancer	637
59	The difference between male and female breast cancer	648
60	Difference in the germ cell tumors of the reproductive tract in men and women	658
61	Gender and gastrointestinal malignancies : incidence and response to treatment	664
62	Gender influences on the development and progression of brain tumors	671
63	Gender difference in hereditary cancer syndromes : risks, management, and testing for inherited predisposition to cancer	682
64	Cancer screening	693
Sect. 8	Nutrition
	Introduction	703
65	Energy requirements of men and women	705
66	Anorexia, bulimia, disordered eating and obesity	715
67	The influence of gender differences in metabolism upon nutritional recommendations for athletes	729
68	Cardiovascular disease, genes, and nutrition : gender matters	737
69	Insulin resistance and type 2 diabetes mellitus : gender differences and similarities	752
70	The role of nutrition in the modulation of sex steroids	759
71	Nutrition and cancers of the breast, endometrium, and ovary	770
72	Nutrition and the etiology and prevention of prostate cancer	783
73	Human papillomavirus infection in men and women : the impact of nutrition on cervical cancer	796
74	Nutritional antioxidants, vitamins, cognition, and neurodegenerative disease	813
Sect. 9	Drug metabolism
	Introduction	825
75	Anticoagulants/antithrombotic therapy	831
76	Pain medications : differences between the sexes	843
77	Evaluation of drugs in women : regulatory perspective	848
78	Gender and antidepressants	860
79	Consideration for the use of therapeutic drugs during pregnancy and the perinatal period	869
80	Weight reduction therapies : anorectants, thermogenics, and lipolytics	874
81	Hormone replacement therapy : looking closely at low dose	882
82	Use of oral contraceptive for contraception	889
Sect. 10	Infectious disease
	Introduction	899
83	Gender and bacterial infections	901
84	Gender-specific issues in fungal infections	910
85	Sex and gender-specific issues in HIV pathogenesis	923
86	Gender-specific issues in the metabolic complications of HIV disease and its treatment	931
87	The effect of gender on the epidemiology, clinical presentation, and management of tuberculosis	938
88	Gender-specific issues in non-HIV viral infections	946
89	Gender-specific issues in parasitology	956
90	Sexually transmitted infections in men and women	966
Sect. 11	Bone
	Introduction	979
91	Corticosteroid-induced osteoporosis : a comprehensive review	981
92	Anabolic therapy of osteoporosis in women and in men	995
93	Antiresorptive therapies of osteoporosis in women and men	1010
94	The role of androgens and estrogens in the male skeleton	1021
95	The clinical application of gender-based databases for the diagnosis of osteoporosis and fracture risk prediction	1033
96	Animal models for gender-based skeletal differences	1043
97	Epidemiology of osteoporosis and fracture in men and women	1052
98	Gender and sports medicine in the adult athlete	1060
Sect. 12	Immunology/Rheumatology
	Introduction	1069
99	Sexual dimorphism and the immune system	1071
100	Estrogen, signal transduction, and systemic lupus erythematosus : molecular mechanisms	1082
101	Sex hormone metabolism, immune function, and the effect of sex hormones on various rheumatic diseases	1093
102	Pregnancy - success or failure : the influence of autoimmune diseases	1106
103	Gender-specific issues in organ transplantation	1116
104	Prolactin in autoimmune disease	1128
Sect. 13	Aging
	Introduction	1139
105	A history of old age in America	1141
106	Breast diseases in older women and men	1154
107	Care of the older woman : practical issues	1163
108	Cancer management in older women	1171
109	The evaluation and treatment of urinary incontinence	1186
110	Effects of aging on gonadotropin/ovarian and growth hormone/ovarian relationships in normal women	1197