Bisphosphonates in Bone Disease : From the Laboratory to the Patient Book

Bone and Mineral Metabolism:
Bone Physiology:
Morphology.
Composition of bone.
Modeling and remodeling.
Calcium homeostasis.
Bone as an organ.
Assessment of bone turnover.
Bisphosphonates-Preclinical:
Background to the pharmacological development:
Chemistry.
Actions.
Physicochemical effects.
Biological effects.
Inhibition of bone resorption.
Inhibition of mineralization.
Pharmocokinetics:
Intestinal absorption.
Distribution.
Renal clearance.
Other modes of application.
Animal toxicology:
Acute toxicology.
Nonacute toxicology.
Bisphosphonates-clinical:
Introduction.
Paget's Disease:
Definition.
Epidemiology.
Pathophysiology.
Clinical manifestations.
Treatment with drugs other than bisphosphonates.
Treatment with bisphosphonates.
Osteolytic tumor-induced bone disease:
Definition.
Pathophysiology.
Clinical manifestations.
Treatment with drugs other than bisphosphonates.
Treatment with bisphosphonates.
Non-tumor induced hypercalcemia:
Definition.
Pathophysiology.
Clinical manifestations.
Treatment with drugs other than bisphosphonates.
Treatment with bisphosphonates.
Osteoporosis:
Definition.
Epidemiology.
Pathophysiology.
Clinical manifestations.
Treatment with drugs other than bisphosphonates.
Treatment with bisphosphonates.
Heterotopic calcification and ossification:
Definition.
Pathophysiology.
Clinical manifestations.
Treatment with drugs other than bisphosphonates.
Treatment with bisphosphonates.
Other diseases:
Adverse events:
Bisphosphonates in general.
Individual bisphosphonates.
Contraindications.
Future prospects.
Commercially available bisphosphonates:
Index.