The Vaccine Book Book

	Contributors
	Preface
	Acknowledgments
1	Global Burden of Disease
A	The Burden of Vaccine-Preventable Diseases
B	Cost Effectiveness of Immunization: Asking the Right Questions
C	Potential and Existing Impact of Vaccines on Disease Epidemiology
2	Immunology
A	Basic Immunology of Vaccine Development
B	Immunological Requirements for Vaccines to Be Used in Early Life
3	Trial Design for Vaccines
A	Clinical Development of New Vaccines: Phase 1 and 2 Trials
B	Phase 3 Studies of Vaccines
4	Ethics and Vaccines
5	Understanding Microbial Pathogenesis as a Basis for Vaccine Design
A	Bacteria
B	Disease-Oriented Approach to the Discovery of Novel Vaccines
C	Immunological Memory and Vaccines against Acute Cytopathic and Noncytopathic Infections
D	Parasitic Diseases, with an Emphasis on Experimental Cutaneous Leishmaniasis
6	Disease States and Vaccines: Selected Cases
A	Introduction
B	Polio
C	Rubella
D	Pertussis
E	Rotavirus
F	AIDS Vaccines: Challenges and Prospects
G	Pneumococcus, Pneumococcal Disease, and Prevention
H	Tuberculosis
I	Malaria
J	Human Papillomaviruses
K	Helicobacter pylori
L	Genome-Based Approach for a Vaccine against Neisseria meningitidis
7	Economics of Vaccines: From Vaccine Candidate to Commercialized Product
8	Vaccine Safety: Real and Perceived Issues
9	Introduction of New Vaccines in the Healthcare System
10	Future Challenges for Vaccines and Immunization