Williams Manual of Hematology, Eighth Edition Book

Ch. 1	Initial approach to the patient : history and physical examination	3
Ch. 2	Examination of the blood	11
Ch. 3	Examination of the marrow	21
Ch. 4	Structure of the marrow and the hematopoietic microenvironment	35
Ch. 5	The lymphoid tissues	73
Ch. 6	Hematology of the newborn	81
Ch. 7	Hematology during pregnancy	101
Ch. 8	Hematology in older persons	111
Ch. 9	Genetic principles and molecular biology	125
Ch. 10	Cytogenetics and gene rearrangement	137
Ch. 11	Apoptosis	151
Ch. 12	Cell cycle regulation and hematological disorders	159
Ch. 13	Signal transduction pathways	173
Ch. 14	The cluster of differentiation (CD) antigens	183
Ch. 15	Hematopoietic stem cells, progenitors, and cytokines	201
Ch. 16	The inflammatory response	221
Ch. 17	Innate immunity	231
Ch. 18	Dendritic cells and the control of innate and adaptive immunity	239
Ch. 19	Pharmacology and toxicity of antineoplastic drugs	249
Ch. 20	Treatment of infections in the immunocompromised host	275
Ch. 21	Principles of antithrombotic therapy	283
Ch. 22	Principles of hematopoietic cell transplantation	301
Ch. 23	Principles of immune cell therapy	323
Ch. 24	Principles of vaccine therapy	333
Ch. 25	Principles of therapeutic apheresis : indications, efficacy, complications	337
Ch. 26	Principles of gene transfer for therapy	345
Ch. 27	Pain management	355
Ch. 28	Morphology of the erythron	369
Ch. 29	Composition of the erythrocyte	387
Ch. 30	Production of erythrocytes	393
Ch. 31	Destruction of erythrocytes	405
Ch. 32	Clinical manifestations and classification of erythrocyte disorders	411
Ch. 33	Aplastic anemia	419
Ch. 34	Pure red cell aplasia	437
Ch. 35	Anemia of chronic renal failure	449
Ch. 36	Anemia of endocrine disorders	459
Ch. 37	The congenital dyserythropoietic anemias	463
Ch. 38	Paroxysmal nocturnal hemoglobinuria	469
Ch. 39	Folate, cobalamin, and megaloblastic anemias	477
Ch. 40	Disorders of iron metabolism	511
Ch. 41	Anemia resulting from other nutritional deficiencies	555
Ch. 42	Anemia associated with marrow infiltration	561
Ch. 43	Anemia of chronic disease	565
Ch. 44	Disorders of the red blood cell membrane : hereditary spherocytosis, elliptocytosis, and related disorders	571
Ch. 45	Disorders of red cells resulting from enzyme abnormalities	603
Ch. 46	Disorders of globin synthesis : the thalassemias	633
Ch. 47	Disorders of hemoglobin structure : sickle cell anemia and related abnormalities	667
Ch. 48	Methemoglobinemia and other causes of cyanosis	701
Ch. 49	Hemolytic anemia resulting from physical injury to red cells	709
Ch. 50	Hemolytic anemia resulting from chemical and physical agents	717
Ch. 51	Hemolytic anemia resulting from infections with microorganisms	723
Ch. 52	Hemolytic anemia resulting from immune injury	729
Ch. 53	Alloimmune hemolytic disease of the newborn	751
Ch. 54	Acute blood loss anemia	767
Ch. 55	Hypersplenism and hyposplenism	773
Ch. 56	Primary and secondary polycythemias (erythrocytosis)	779
Ch. 57	The hematologic aspects of porphyria	803
Ch. 58	Hereditary and acquired sideroblastic anemias	823
Ch. 59	Morphology of neutrophils, eosinophils, and basophils	831
Ch. 60	Composition of neutrophils	847
Ch. 61	Production, distribution, and fate of neutrophils	855
Ch. 62	Eosinophils and their disorders	863
Ch. 63	Basophils and mast cells and their disorders	879
Ch. 64	Classification and clinical manifestations of neutrophil disorders	899
Ch. 65	Neutropenia and neutrophilia	907
Ch. 66	Disorders of neutrophil function	921
Ch. 67	Morphology of monocytes and macrophages	961
Ch. 68	Biochemistry and function of monocytes and macrophages	971
Ch. 69	Production, distribution, and fate of monocytes and macrophages	979
Ch. 70	Classification and clinical manifestations of disorders of monocytes and macrophages	983
Ch. 71	Monocytosis and monocytopenia	987
Ch. 72	Inflammatory and malignant histiocytosis	993
Ch. 73	Lipid storage diseases	1009
Ch. 74	Morphology of lymphocytes and plasma cells	1023
Ch. 75	Composition and biochemistry of lymphocytes and plasma cells	1031
Ch. 76	Lymphopoiesis	1039
Ch. 77	Functions of B lymphocytes and plasma cells in immunoglobulin production	1051
Ch. 78	Functions of T lymphocytes : T cell receptors for antigen	1065
Ch. 79	Functions of natural killer cells	1077
Ch. 80	Classification and clinical manifestations of lymphocyte and plasma cell disorders	1083
Ch. 81	Lymphocytosis and lymphocytopenia	1087
Ch. 82	Immunodeficiency diseases	1099
Ch. 83	Hematological aspects of human immunodeficiency syndrome	1109
Ch. 84	Mononucleosis syndromes	1135
Ch. 85	Classification and clinical manifestations of the clonal myeloid disorders	1147
Ch. 86	Myelodysplastic syndromes (clonal cytopenias and oligoblastic leukemia)	1157
Ch. 87	Acute myelogenous leukemia	1183
Ch. 88	Chronic myelogenous leukemia and related disorders	1237
Ch. 89	Idiopathic myelofibrosis (myelofibrosis with myeloid metaplasia)	1295
Ch. 90	Classification of malignant lymphoid disorders	1315
Ch. 91	Acute lymphoblastic leukemia	1321
Ch. 92	Chronic lymphocytic leukemia and related diseases	1343
Ch. 93	Hairy cell leukemia	1385
Ch. 94	Large granular lymphocytic leukemia	1395
Ch. 95	Pathology of lymphomas	1399
Ch. 96	The non-Hodgkin lymphomas	1407
Ch. 97	Hodgkin lymphoma	1461
Ch. 98	Plasma cell neoplasms : general considerations	1483
Ch. 99	Essential monoclonal gammopathies	1491
Ch. 100	Plasma cell myeloma	1501
Ch. 101	The amyloidoses	1535
Ch. 102	Macroglobulinemia	1549
Ch. 103	Heavy chain diseases	1561
Ch. 104	Megakaryopoiesis and thrombopoiesis	1571
Ch. 105	Platelet morphology, biochemistry, and function	1587
Ch. 106	Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis	1665
Ch. 107	Control of coagulation reactions	1695
Ch. 108	Vascular function in hemostasis	1715
Ch. 109	Classification, clinical manifestations, and evaluation of disorders of hemostasis	1741
Ch. 110	Thrombocytopenia	1749
Ch. 111	Essential thrombocythemia and thrombocytosis	1785
Ch. 112	Hereditary qualitative platelet disorders	1795
Ch. 113	Acquired qualitative platelet disorders	1833
Ch. 114	The vascular purpuras	1857
Ch. 115	Hemophilia A and hemophilia B	1867
Ch. 116	Inherited deficiencies of coagulation factors II, V, VII, X, XI, and XIII and combined deficiencies of factors V and VIII and of the vitamin K-dependent factors	1887
Ch. 117	Hereditary fibrinogen abnormalities	1909
Ch. 118	Von Willebrand disease	1929
Ch. 119	Antibody-mediated coagulation factor deficiencies	1947
Ch. 120	Hemostatic dysfunction related to liver diseases and liver transplantation	1953
Ch. 121	Disseminated intravascular coagulation	1959
Ch. 122	Hereditary thrombophilia	1981
Ch. 123	The antiphospholipid syndrome	2009
Ch. 124	Antibody-mediated thrombotic disorders : idiopathic thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia	2031
Ch. 125	Venous thrombosis	2055
Ch. 126	Atherothrombosis : disease initiation, progression, and treatment	2067
Ch. 127	Fibrinolysis and thrombolysis	2089
Ch. 128	Erythrocyte antigens and antibodies	2119
Ch. 129	Human leukocyte and platelet antigens	2137
Ch. 130	Blood procurement and screening	2151
Ch. 131	Preservation and clinical use of erythrocytes and whole blood	2159
Ch. 132	Preservation and clinical use of platelets	2175