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Preface ix
Introduction 1
General Principles 9
Medications as Chemicals 9
Classification of Medications Acting on the Nervous System 10
Blood-Brain Barrier 11
Pharmacokinetics and Pharmacodynamics 13
Drug Action and Human Variation 18
Talk Therapy and Drug Therapy 20
Mood Disorders: Depression and Mania 25
Depression 26
Mania 35
Manic-Depressive Disease 36
Suicide 38
Medications for Depression 42
Medications for Mania and Manic-Depressive Illness 60
Treatment of Acute Psychosis by the General Clinician 69
Nonpharmacological Treatments 70
Thought Disorders: Including Schizophrenias and Related Psychoses 75
Classification and Diagnosis 78
Neurobiology 81
Treatment 86
Treatment of Acute Psychotic Emergencies 99
Nonpharmacological Treatments 100
Cognitive Disorders: Delirium and Dementia 105
Incidence and Prevalence 106
Classification and Diagnosis 107
Neurobiology of Delirium and Dementia: General Considerations 127
Pathophysiology of Specific Forms of Dementia 131
Treatment 136
Anxiety 163
Classification and Diagnosis 164
Neurobiology 173
Treatment 174
Pain 185
Classification and Diagnosis 185
Neurobiology 195
Treatment 197
Sleep 225
Classification and Diagnosis 226
Neurobiology 235
Treatments 240
Cerebrovascular Disorders 255
Classification and Diagnosis 256
Neurobiology 266
Treatment 267
Disorders of Awareness: Dizziness, Fainting, Fits, Stupor, and Coma and Related Conditions 283
Dizziness 284
Fainting 286
Fits (Seizures) 289
Stupor 303
Coma 303
Brain Stem Compression (Herniation, "Coning") 309
Other Conditions 313
Disorders of Motility: Including Parkinson Disease and Other Movement Disorders 319
Classification and Diagnosis 320
Diagnostic Considerations for Disorders of Motility Involve both Questions of Mechanism and Recognition of Certain Common Syndromes (Clinical Entities) 331
Neurobiology 341
Treatment 348
Disorders of Sensation 371
Classification and Diagnosis 371
Disorders of Special Sensations 372
Neurobiology 383
Treatment 385
Disorders of Both Sensation and Motility: Multiple Sclerosis and Related Disorders; Neuropathies 391
Multiple Sclerosis (MS) 392
Other Disorders of Myelin 401
Motor-Sensory Neuropathies 403
Disorders of Conduct 415
Learned Maladaptive Behavior 415
Somatoform Disorders 417
Sexual Disorders 422
Personality Disorders 428
Adjustment Disorders and Posttraumatic Stress Disorder 435
Impulse Control Disorders 436
Addiction/Substance Abuse 438
Index 469
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