The Vault of Horror was a bi-monthly horror comic anthology series published by EC Comics in the early 1950s. Along with Tales from the Crypt and The Haunt of Fear, it formed a trifecta of popular EC horror anthologies. The Vault of Horror hit newsstands with its April/May 1950 issue and ceased publication with its December/January 1955 issue, producing a total of 29 issues.
In 1950, Gaines and his editor Al Feldstein discovered they shared similar tastes in horror and began experimenting with such stories in EC's crime comic War Against Crime and its companion title, Crime Patrol. With issue #12 the War Against Crime title was replaced with The Vault of Horror. The Vault-Keeper became the title's sardonic host and commentator, occasionally sharing duties with the Old Witch and the Crypt-Keeper. Due to an attempt to save money on second-class postage permits, characteristic of comics publishing of the era, the numbering did not change with the title; the first issue of The Vault of Horror was thus labelled "No. 12". There is, however, evidence of an intention to reset the series' numbering with the fourth issue (#15), as was done with The Haunt of Fear (the numbering of which was reset, yet also "continued" by Two-Fisted Tales: a few copies survive of the first issue of Crime SuspenStories with a different indicia on the inside front cover. As the Overstreet Comic Book Price Guide explains: "#15 (formerly The Vault of Horror)" printed and blackened out on inside front cover with "Vol.1, No.1" printed over it. Evidently, several of No.15 were printed before a decision was made not to drop the Vault of Horror and Haunt of Fear series. The print run was stopped on No.15 and continued on No.1. All of the No.15 issues were changed as described above."