The Macrophage As Therapeutic Target Book

Preface.- Section I: General.- 1. The macrophage as a validated pharmaceutical target.2. Transcription factors that regulate macrophage development & function.3. Exploitation of macrophage clearance functions in vivo.4. Reaching the macrophage - routes of delivery.5. Antigen presenting cells & vaccine design.6. Macrophage-specific gene targeting in vivo.- Section II: Macrophage targets in inflammation.- 7. Integrins of macrophage & macrophage-like cells.8. Purinergic receptors.9. Macrophage lipid uptake & foam cell formation.10. Dietary fatty acids and macrophages.11. Macrophages as therapeutic targets in lysosomal storage disorders.12. Nuclear receptors as regulators of macrophage homeostasis & function.13. Relationships between reactive oxygen species & reactive nitrogen oxide species produced by macrophages.14. Proteases.15. Targeting the chemokine system.16. Antimicrobial peptides.17. Macrophage phospholipid products.- Section III: Modulation of specialised macrophage activities.- 18. Dendritic cells versus macrophages as antigen presenting cells; common and unique features.19. The osteoclast .20. Macrophages in the central and peripheral nervous system.21. Innate recognition of viruses by macrophage and related receptors: potential ligands for antiviral agents.22. Macrophages & Mycobacterium tuberculosis.23. Detection & control of fungi by macrophages: the role of carbohydrates and antifungal agents.