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The Reference Materials of the European Communities: Results of Hemocompatibility Tests Book

The Reference Materials of the European Communities: Results of Hemocompatibility Tests
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  • The Reference Materials of the European Communities: Results of Hemocompatibility Tests
  • Written by author Wilfried Lemm
  • Published by Springer-Verlag New York, LLC, November 1992
  • The demand for hemocompatibility is one of the fundamental requirements for a safe and sufficient application of artificial surfaces in contact with blood. Thrombus formation and infarctions of the capillary vascular system after blood-biomaterial interac
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Foreword
The Concerted Action EUROBIOMAT -Hemocompatibility-
Introduction
General Information and Instructions
Pt. IPhysical, Chemical and Physico-chemical Methods for Surface and Bulk Characterisation
Surface Characterization of EUROBIOMAT Reference Polymers3
Surface Analysis of Polymer Biomaterials by Electron Spectroscopy for Chemical Analysis (ESCA)17
Surface Infrared Analysis of Standard Biomaterials27
Contact Angles on Polymer Reference Materials37
Zeta-Potentials and Surface Tensions49
The Surface Energy Spectra of Polymers65
Supercritical Fluid Extraction / Chromatography (SFE/C) of Additives from Standard Biomaterials for Use in Biocompatibility Testing75
Determination of Surface Energetic Properties by Contact Angle Measurements85
Advancing and Receding Water Contact Angle Measurements with Drops, Bubbles and Plates95
Screening Test for Residual Ethylene Oxide on Reference Materials107
The Average Molecular Weight of the Reference Materials113
Pt. IIBiological, Biochemical, Immunological, Hematological and Toxicological Methods to Evaluate the Biocompatibility of the Reference Materials
Activation of the Human Complement System by "Standard" Polymers121
Photometric Enzyme Immunoassay for the Quantitative Determination of C3a-des Arg in Human Plasma Incubated with Polymeric Biomaterials127
Complement Activation, Cytotoxicity and Leaching of Substances139
Enzyme-Linked Immunosorbent Assays for Biocompatibility Testing147
Measurement of Platelet Adhesion, released [beta]-Thromboglobulin and Generated Fibrinopeptide A Using whole Non-anti-coagulated Blood at Flow Conditions157
Perfusion Technique for in vitro Evaluation of Platelet Interaction with Biomaterials in Catheter Form165
In-vitro Hemocompatibility Screening Test by Using the Resonance-Thrombography173
The Hemocompatibility of Reference Materials in-vitro; Comparative Investigation of Platelet Adhesion/Activation and Platelet Aggregability183
Cell Culture Cytotoxicity Assays as Part of the Biocompatibility Testing of Standard Biomaterials193
Quantitative Evaluation of Cytotoxicity in vitro of Extracts from Standard Biomaterials201
In-vitro Toxicity of the Reference Materials. The Ciliata-Test211
Keratinocyte Cell Cultures for Testing Polymers for Percutaneous Devices217
Blood-Testing of a Polyether-Urethane as a Diffusion Limiting and Potentially Haemocompatible External Membrane for Enzyme Electrode Biosensors227
Biocompatibility Evaluation of Reference Materials237


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