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Structural bioinformatics Book

Structural bioinformatics
Structural bioinformatics, The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helg, Structural bioinformatics has a rating of 4 stars
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Structural bioinformatics, The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helg, Structural bioinformatics
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  • Structural bioinformatics
  • Written by author Philip E. Bourne, Helge Weissig
  • Published by Hoboken, N.J. : Wiley-Liss, c2003., 2003/03/11
  • "The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helg
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Book Categories

Authors

Foreword
Preface
Acknowledgments
Contributors
Sect. I Introduction 1
1 Defining Bioinformatics and Structural Bioinformatics 3
2 Fundamentals of Protein Structure 15
3 Fundamentals of DNA and RNA Structure 41
4 Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination 75
5 Macromolecular Structure Determination by NMR Spectroscopy 89
6 Electron Microscopy 115
7 Molecular Visualization 135
Sect. II Data Representation and Databases 159
8 The PDB Format, mmCIF Formats, and Other Data Formats 161
9 The Protein Data Bank 181
10 The Nucleic Acid Database 199
11 Other Structure-Based Databases 217
Sect. III Comparative Features 237
12 Protein Structure Evolution and the Scop Database 239
13 The Cath Domain Structure Database 249
14 Structural Quality Assurance 273
15 All-Atom Contacts: A New Approach to Structure Validation 305
16 Structure Comparison and Alignment 321
Sect. IV Structure and Functional Assignment 339
17 Secondary Structure Assignment 341
18 Identifying Structural Domains in Proteins 365
19 Inferring Protein Function from Structure 387
Sect. V Protein Interactions 409
20 Prediction of Protein - Protein Interactions from Evolutionary Information 411
21 Electrostatic Interactions 427
Sect. VI Proteins as Drug Targets 441
22 Principles and Methods of Docking and Ligand Design 443
23 Structural Bioinformatics in Drug Discovery 477
Sect. VII Structure Prediction 499
24 CASP and CAFASP Experiments and their Findings 501
25 Homology Modeling 509
26 Fold Recognition Methods 525
27 AB Initio Methods 547
28 Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility 559
Sect. VIII The Future 589
29 Structure Genomics 591
Index 613


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