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Purinergic Experimental Therap Book

Purinergic Experimental Therap
Purinergic Experimental Therap, Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr, Purinergic Experimental Therap has a rating of 3 stars
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Purinergic Experimental Therap, Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr, Purinergic Experimental Therap
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  • Purinergic Experimental Therap
  • Written by author Jacobson
  • Published by Wiley, John & Sons, Incorporated, July 1997
  • Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr
  • Edited by Kenneth A. Jacobson and Michael F. Jarvis The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning an
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Preface
Pt. IHistorical Perspective1
1Purinergic Neurotransmission and Neuromodulation: A Historical Perspective3
Pt. IIMolecular Pharmacology27
2Adenosine Receptor Subtypes: New Insights From Cloning and Functional Studies29
3Structure, Pharmacological Selectivity, and Second Messenger Signaling Properties of G Protein - Coupled P2-Purinergic Receptors39
4Regulators of Endogenous Adenosine Levels as Therapeutic Agents55
5Allosteric Enhancement of Adenosine Receptors85
Pt. IIIMedicinal Chemistry99
6Development of Selective Purinoceptor Agonists and Antagonists101
7Modulators of Adenosine Uptake, Release, and Inactivation129
Pt. IVTherapeutic Implications149
8Adenosine, Ischemia, and Preconditioning153
9ATP as a Cotransmitter With Noradrenaline in Sympathetic Nerves - A Target for Hypertensive Therapy?173
10Cardiac Eletrophysiology of Adenosine: Antiarrhythmic and Proarrhythmic Actions185
11The Role of ADP in Thrombosis and the Therapeutic Potential of P[subscript 2T]-Receptor Antagonists as Novel Antithrombotic Agents203
12Renal Action of Purines217
13P[subscript 2] Purinoceptor Agonists: New Insulin Secretagogues Potentially Useful in the Treatment of Non-Insulin-Dependent Diabetes Mellitus253
14Purinergic Modulation of Gastrointestinal Function261
15Adenosine Regulation of Neutrophil Function and Inhibition of Inflammation via Adenosine Receptors285
16Purinergic Modulation of Septic Shock and Systemic Inflammation Response Syndrome301
17The Role of Adenosine in Asthma315
18Nucleotides and Nucleosides in Pulmonary Function333
19Adenosine Neuromodulation359
20ATP in Brain Function383
21Psychomotor Aspects of Adenosine Receptor Activation405
22Adenosine and ATP in Epilepsy423
23Adenosine and Acute Treatment of Cerebral Ischemia and Stroke - "Put Out More Flags"449
24Purines in Anesthesia471
25Purines and Nociception495
26Adenosine Effects in Sleep Apnea515
27The Influence of Adenosine on the Developing Fetus527
28ATP in the Treatment of Cancer545
Index555


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Purinergic Experimental Therap, Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr, Purinergic Experimental Therap

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Purinergic Experimental Therap, Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr, Purinergic Experimental Therap

Purinergic Experimental Therap

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Purinergic Experimental Therap, Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expr, Purinergic Experimental Therap

Purinergic Experimental Therap

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