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Pharmacophore Perception, Development and Use in Drug Design Book

Pharmacophore Perception, Development and Use in Drug Design
Pharmacophore Perception, Development and Use in Drug Design, , Pharmacophore Perception, Development and Use in Drug Design has a rating of 3 stars
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  • Pharmacophore Perception, Development and Use in Drug Design
  • Written by author Osman F. Guner
  • Published by International University Line, March 2000
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In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMF A; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores.


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