Pharmaceutical Perspectives of Nucleic Acid-Based Therapy Book

	List of color plates
	List of figures
	List of tables
	List of contributors
	Foreword
	Preface
1	Basic components of gene expression plasmids	1
2	Inducible gene expression strategies in gene therapy	15
3	Modulation of gene expression by antisense oligonucleotides	33
4	Ribozymes as therapeutic agents and genetic tools	54
5	Peptide nucleic acids (PNA) binding-mediated target gene transcription	73
6	Aptamers for controlling gene expression	89
7	Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy	121
8	Compaction and condensation of DNA	136
9	Structure, dispersion stability and dynamics of DNA and polycation complexes	164
10	Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery	190
11	Cellular uptake, metabolic stability and nuclear translocation of nucleic acids	210
12	Nucleocytoplasmic Trafficking	229
13	Optimizing RNA export for transgene expression	261
14	Naked plasmid DNA delivery of a therapeutic protein	285
15	Cationic lipid-based gene delivery	302
16	Peptide-based gene delivery systems	334
17	Cationic and non-condensing polymer-based gene delivery	367
18	Device-mediated gene delivery	388
19	Basic pharmacokinetics of oligonucleotides and genes	409
20	Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors	434
21	Hepatic delivery of nucleic acids using hydrodynamics-based procedure	455
22	Role of CpG motifs in immunostimulation and gene expression	469
23	Local cardiovascular gene therapy	487
24	Gene therapy for cardiovascular disease	499
25	Gene therapy for the prevention of autoimmune diabetes	508
	Index	520