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Part I. Genomics, Cancer Targets, Transcriptomics, and Gene Expression Analysis
Genomic Resources for Cancer Biologists
Xuefeng Bruce Ling, Gene Cutler, and Timothy Hoey
Cancer Drug Target Identification by SAGE, LongSAGE, and Digital Karyotyping
Heiko Hermeking
Identification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence Databases
Tapan K. Bera, Kristi A. Egland, B. K. Lee, and Ira Pastan
Tree-Based Cancer Classification and Diagnosis Using Gene Expression Data
Heping Zhang
From FISH to Proteomics: A Molecular Brush to Define Antitumor Drug Action
Balanehru Subramanian, Alexander Nakeff, and Frederick Valeriote
Gene Program Signatures for Papillomavirus E2-Mediated Senescence in Cervical Cancer Cells: Finding the Points of No Return
Sarah S. Williams, Bruce J. Aronow, and Susanne I. Wells
Part II. Advances in Proteomic and Enzymatic Cancer-Profiling Technologies
Mass-Spectrometry-Based Proteomics for Cancer Biology
Chen Xu and John R. Yates III
Chemical Proteomics in Drug Development
Douglas A. Jeffery, Amos Baruch, and Matthew Bogyo
Proteomics-Based Anticancer Drug Discovery
K. K. Jain
Cancer Metabolic Phenotype: Exploiting the Cancer Metabolome in Drug Discovery
John R. Griffiths and Marion Stubbs
Focusing Target Discovery and Validation Through Proteogenomics and Molecular Imaging
Lucy A. Carver and Jan E. Schnitzer
Part III. Cancer Target Validation: Cellular Approaches
RNA Interference: RNAid for Future Therapeutics?
Mustapha Diallo, Katja Schmitz, and Ute Schepers
Image-Based Assays of Cellular Phenotype for Drug Target Discovery and Validation
Kris F. Sachsenmeier and Jonathan A. Terrett
Targeting Inducible Chemotherapy Resistance Mechanisms in Colon Cancer
David Ljungman and James C. Cusack, Jr.
Targeting Apoptosis Pathways for Cancer Therapy
Bharvin K. R. Patel
Part IV. Cancer Target Validation: Animal Approaches
Genetically Engineered Mouse Models of Human Cancer for Drug Discovery and Development
Rónán C. O'Hagan, Min Wu, William M. Rideout III, Yinghui Zhou, and Joerg Heyer
Unraveling the Complexity of Oncogenesis Through In Vivo Optical Imaging
Pamela Reilly Contag
Innovative Strategies for Improving Engineered Mouse Models of Human Cancer for Preclinical Development
Jeffrey J. Martino and Suzie Chen
Use of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel Genes
Jeff L. Ellsworth, Andrew Feldhaus, and Steven D. Hughes
Cancer Biology and Transgenic Technology in the Mouse: Bridging the Functional Gap
Cindy E. McKinney and Cooduvalli S. Shashikant
Homology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides: PDGF-D
Gary C. Starling, William J. LaRochelle, and Gulshan Ara
Part V. Cancer Prognostics, Diagnostics, and Biomarkers
Cancer Pharmacogenomics: Predicting Drug Response in the Genomic Era
Brian Z. Ring and Huijun Z. Ring
Diagnosis and Treatment of Malignancies Using Gene Expression Profiling
Jimmy C. Sung, Alice Y. Lee, and Timothy J. Yeatman
Implications of Epigenetics for Early Cancer Diagnosis and Prevention
Mukesh Verma and Sudhir Srivastava
Novel Molecular and Genetic Prognostic Biomarkers in Prostate Cancer
Arnab Chakravarti and Gary Guotang Zhai
PSA in Prostate Cancer Diagnosis
Pradip Datta
Tumor Targets and Biomarkers in Renal Cell Carcinoma
Ivar Bleumer and Peter F. A. Mulders
Part VI. Emerging Approaches to Cancer Therapy
VI-A. Targeting the Vasculature
Tumor Vasculature as a Target for Cancer Therapy
Grzegorz Korpanty, Xianming Huang, and Rolf A. Brekken
Targeting the VEGF/VEGFR Axis for Cancer Therapy
Frank A. Scappaticci
Inhibiting Cancer Angiogenesis With Molecular Therapy
Qixin Leng and A. James Mixson
VI-B. Supportive and Adjuvant Therapies
Development of Palifermin (rHuKGF) for Mucositis
Ping Wei and Catherine L. Farrell
Immune Modulation: The B7 Family Cosignaling Molecules as Emerging Targets for Enhancing Cancer Therapy
Sheng Yao and Lieping Chen
VI-C. Tumor-Targeted Therapies
Proteasome Inhibition and Its Clinical Application in Solid Tumors
David J. Park and Heinz-Josef Lenz
Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy
Anas Younes and Andrea Cerutti
Small-Molecule Receptor Tyrosine Kinase Inhibitors in Targeted Cancer Therapy
Carlos García-Echeverría
The mTOR Pathway and Its Inhibitors
John B. Easton and Peter J. Houghton
Cyclo-Oxygenase-2 Enzyme and Its Inhibition in Tumor Growth and Therapy
Zhongxing Liao, Uma Raju, Kathryn A. Mason, and Luka Milas
Understanding Prostate-Specific Membrane Antigen and Its Implication in Prostate Cancer
Arundhati Ghosh and Warren D. W. Heston
Development of a Radiolabeled Monoclonal Antibody to Prostate-Specific Membrane Antigen
Stanley J. Goldsmith, Shankar Vallabhajosula, Matthew I. Milowsky, David M. Nanus, Lale Kostakoglu, and Neil H. Bander
Monoclonal Antibody Strategies for Targeting HER2
Joan Albanell, Jeffrey S. Ross, Linda Pronk, and Pere Gascon
From XenoMouse® Technology to Panitumumab (ABX-EGF)
Xiaodong Yang, Lorin Roskos, C. Geoffrey Davis, and Gisela Schwab
Development and Evaluation of Cancer Therapeutic Agents Targeting TRAIL Receptor 1 and 2
Robin C. Humphreys
Clinical Studies of Immunotherapy With Rituximab (Rituxan®) and Radioimmunotherapy With Ibritumomab Tiuxetan (Zevalin®) in B-Cell Lymphoid Malignancies
Arturo Molina
Part VII. Informatics Strategies and Initiatives
Informatics Strategies and Initiatives Used in Cancer Research
Martin D. Leach
Index
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