Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia: Invited Papers from the International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia, Okayama, Japan 18-20 October 2002, ICS 125 Book

	Preface
	Acknowledgements
	Expression of PTEN and its phosphorylated form after transient middle cerebral artery occlusion in rat
	CRE-mediated gene expression in cerebral ischemia	13
	Poly (ADP-ribose) polymerase and brain ischemia	21
	Effect of angiotensin II on cerebral edema following cerebral ischemia and reperfusion	31
	High-density DNA microarray analysis of gene expression following transient focal cerebral ischemia in mouse	45
	Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord of the mice with mutant human SOD1 gene	57
	Early decrease of survival signal protein and DNA repair enzyme in spinal motor neuron of presymptomatic transgenic mice with a mutant SOD1 gene	65
	Alteration in survival signal induction by transient hypoxia in mice expressing mutant human SOD1 protein	73
	Renin-angiotensin system gene polymorphism in Japanese stroke patients	83
	Mild hypothermia enhances efficacy of neuroprotective agents in cerebral ischemia in rats	93
	Effects of aging on hypothermic neuroprotection in acute stroke	103
	The effects of a free radical scavenger, edaravone, combined with mild hypothermia on ischemic brain damage following transient middle cerebral artery occlusion in rats	109
	Immunophilin ameliorates apoptotic neuronal cell death	117
	Expression of FKBP12 after brain ischemia	123
	Effects of FK506 on chronic cerebral hypoperfusion-induced discrimination learning disabilities in Wistar rats	129
	FK506 facilitates the normalization of post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors	135
	Nuclear factor-kappa B decoy protects spinal cord injury following ischemia/reperfusion in rats	141
	Functional modulation of astrocytes by a novel agent ONO-2506 mitigates delayed infarct expansion with a wide therapeutic time window, inducing prompt neurological recovery through reduction of the extracellular level of glutamate	147
	Caspases and upstream mechanisms in central nervous system ischemic injury	155
	Spatiotemporal changes of free cholesterol and neutral lipids after transient focal cerebral ischemia in rats	163
	Apolipoprotein E influences neuronal death and repair	171
	Suppression of protein synthesis after transient cerebral ischemia	179
	New vessel formation and expression of angiogenesis-related genes in brain after ischemia	193
	Therapeutic time window of rt-PA on embolic stroke in rat	203
	Expression of LOX-1 in spontaneously hypertensive rat carotid atherosclerotic lesions	209
	Expression of p-ERK and cytochrome C signals in rat brain neurons after transient MCAO	213
	Protection against ischemic brain damage by GDNF affecting cell survival and death signals	221
	Neuroprotection by drug-induced growth factors	235
	Neurotrophic factor delivery by encapsulated cell grafts	247
	Gene therapy for cerebral arteries	253
	Therapeutic time window of glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat	259
	Therapeutic time window of Ad-GDNF after transient middle cerebral artery occlusion in rat	265
	Attenuation of neuronal cell death by SOD1 is associated with extracellular signal-regulated kinase after transient focal cerebral ischemia in mice	275
	Adenovirus-mediated gene transfer to ischemic brain	285
	The change of distribution and mRNA expression of brain-derived neurotrophic factor after intrastriatal hemorrhage	291
	Assessment of neuroreceptor changes in healthy ageing and in Alzheimer's disease with emission tomography	299
	MR imaging in acute stroke	309
	New MEG technology for evaluating focal brain function	315
	Imaging of remote areas after focal cerebral ischemia	321
	Propagation of recurrent depolarization in the penumbra in the rat - use of in vivo cortical NADH fluorescence	329
	Quantitative aspects of neurovascular interaction	337
	Predicting the pathological fate of focal cerebral ischemia using [superscript 1]H-magnetic resonance spectroscopic imaging	341
	Distinct functions in tau isoforms in Alzheimer's disease	347
	[gamma]-Cleavage and [epsilon]-cleavage of [Beta]-amyloid precursor protein	355
	COX-2 expression in brains of patients with familial Alzheimer's disease	363
	Accumulation of amyloid [Beta] protein in Tg2576 mice	373
	Molecular pathology of transgenic tau mice	379
	Heat shock proteins reduce aggregation and facilitate degradation of tau protein	383
	Alzheimer's disease and melatonin	395
	A[beta]42 vaccine on the Tg2576 Alzheimer model mice	399
	A[beta] vaccination of a genetic model of Alzheimer's disease
	Somatosensory-evoked fields in Alzheimer's disease	411
	Highly polysialylated neural cell adhesion molecule positive cell increased and changed localization in rat hippocampus with exposure to repeated kindled seizures	419
	Activation of neural stem cells after global brain ischemia	427
	Activation and proliferation of oligodendrocyte progenitor cells after brain ischemia in the rat	435
	Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus	445
	Comparison of proliferation of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia	451
	Differentiation of bone marrow cells in culture and in vivo	461
	Treatment of stroke with marrow stromal cells	465
	Transplantation of mesenchymal stem cells derived from the bone marrow into the demyclinated spinal cord	471
	Transplantation of neural stem cells into ischemic brain	477
	Cell therapy for cerebral ischemia using vascular endothelial growth factor-secreting cells	483
	Transplantation of neural stem cells into epileptic brain
	Neural stem cells as therapeutic agents for CNS injuries and disorders	493
	Author index	499
	Keyword index	503