Lymphocyte Signalling : Mechanisms, Subversion, and Manipulation Book

	List of Contributors
	Preface
Pt. I	Signalling Via the Antigen Receptors on B and T Cells - From the Receptor to the Nucleus
1	Antigen Receptor Structure and Signalling in B Cells	3
2	Antigen Receptor Structure and Signalling in T Cells	31
Pt. II	Accessory Molecule Signalling in B and T Cells
3	CD19 and CR2 on B Lymphocytes: Structure, Biochemistry and Function	53
4	CD23 and T-B Cell Interactions	65
5	The Enigma of CD38, a Multifunctional Ectoenzyme	71
6	CD40 Signalling in T-dependent B Cell Responses	77
7	The T Cell Costimulatory Molecule CD28 Couples to Multiple Signalling Pathways	91
8	The Role of the CD45 Phosphotyrosine Phosphatase in Lymphocyte Signalling	107
9	Signalling via MHC Molecules	141
Pt. III	Life or Death: Signalling Throughout B and T Cell Development
10	Scenes from a Short Life: Checkpoints and Progression Signals for Immature B Cell Life Versus Apoptosis	165
11	Early Response Genes and B Cell Activation	183
12	Signalling for Thymocyte and T Cell Apoptosis	203
13	The Role of Tyrosine Kinases in T Cell Development	227
14	Cyclic Nucleotide Signalling Throughout T Cell Maturation	247
15	Cytokines of the Immunoglobulin Superfamily: Signalling Through the Interleukin-1 Receptor	267
16	Haemopoietic Growth Factors and Their Receptors	289
17	Cytokines and Transcription Factors in Regulation of Lymphocyte Function	309
Pt. IV	Disease and Disruption of Lymphocyte Signalling - Immunopharmacology and Potential Sites of Therapeutic Intervention
18	X-linked Agammaglobulinaemia, an Inherited Deficiency of Antibody Production	339
19	The IL-2R[gamma] Chain in X-linked Severe Combined Immunodeficiency (SCIDX1)	359
20	T Cell Activation Deficiencies and Disease	373
21	HIV and Disruption of T Cell Signalling	407
22	Manipulation of Lymphocyte Signal Transduction Pathways by Eukaryotic Parasites	419
23	Immunophilin-mediated Inhibition of Lymphocyte Signalling	431
	Index	451